Clyde E. Keeler

The Rodless Mouse and the Early Days of Retinal Genetic Research

Research output: Contribution to journalArticle

Abstract

Purpose: To report the lifetime activities and accomplishments of Clyde E. Keeler (1900–1994), a pioneer in the study of retinal genetics. Design: Retrospective review. Methods: Assessment of published and unpublished biographical material. Results: Nearly a century ago, Keeler discovered an inherited abnormality in the mouse that causes the absence of rod photoreceptors and is the mouse counterpart of 1 type of human retinitis pigmentosa. Conclusions: In 1923, Keeler serendipitously discovered the so-called rodless mouse, which is now known to be the result of a mutation in the PDEGB gene. The historical name for the mouse strain is rd. This same defect was reported in human patients with retinitis pigmentosa in 1993. Keeler's mouse model is still used in gene therapy studies seeking to cure retinitis pigmentosa.

Original languageEnglish (US)
Pages (from-to)716-723
Number of pages8
JournalOphthalmology Retina
Volume3
Issue number9
DOIs
StatePublished - Sep 1 2019

Fingerprint

Genetic Research
Retinitis Pigmentosa
Retinal Rod Photoreceptor Cells
Genetic Therapy
Names
Mutation
Genes

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Clyde E. Keeler : The Rodless Mouse and the Early Days of Retinal Genetic Research. / Albert, Daniel.

In: Ophthalmology Retina, Vol. 3, No. 9, 01.09.2019, p. 716-723.

Research output: Contribution to journalArticle

@article{aa245ef8c00c4d2b9d6126bd195021c3,
title = "Clyde E. Keeler: The Rodless Mouse and the Early Days of Retinal Genetic Research",
abstract = "Purpose: To report the lifetime activities and accomplishments of Clyde E. Keeler (1900–1994), a pioneer in the study of retinal genetics. Design: Retrospective review. Methods: Assessment of published and unpublished biographical material. Results: Nearly a century ago, Keeler discovered an inherited abnormality in the mouse that causes the absence of rod photoreceptors and is the mouse counterpart of 1 type of human retinitis pigmentosa. Conclusions: In 1923, Keeler serendipitously discovered the so-called rodless mouse, which is now known to be the result of a mutation in the PDEGB gene. The historical name for the mouse strain is rd. This same defect was reported in human patients with retinitis pigmentosa in 1993. Keeler's mouse model is still used in gene therapy studies seeking to cure retinitis pigmentosa.",
author = "Daniel Albert",
year = "2019",
month = "9",
day = "1",
doi = "10.1016/j.oret.2019.04.019",
language = "English (US)",
volume = "3",
pages = "716--723",
journal = "Ophthalmology Retina",
issn = "2468-7219",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Clyde E. Keeler

T2 - The Rodless Mouse and the Early Days of Retinal Genetic Research

AU - Albert, Daniel

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Purpose: To report the lifetime activities and accomplishments of Clyde E. Keeler (1900–1994), a pioneer in the study of retinal genetics. Design: Retrospective review. Methods: Assessment of published and unpublished biographical material. Results: Nearly a century ago, Keeler discovered an inherited abnormality in the mouse that causes the absence of rod photoreceptors and is the mouse counterpart of 1 type of human retinitis pigmentosa. Conclusions: In 1923, Keeler serendipitously discovered the so-called rodless mouse, which is now known to be the result of a mutation in the PDEGB gene. The historical name for the mouse strain is rd. This same defect was reported in human patients with retinitis pigmentosa in 1993. Keeler's mouse model is still used in gene therapy studies seeking to cure retinitis pigmentosa.

AB - Purpose: To report the lifetime activities and accomplishments of Clyde E. Keeler (1900–1994), a pioneer in the study of retinal genetics. Design: Retrospective review. Methods: Assessment of published and unpublished biographical material. Results: Nearly a century ago, Keeler discovered an inherited abnormality in the mouse that causes the absence of rod photoreceptors and is the mouse counterpart of 1 type of human retinitis pigmentosa. Conclusions: In 1923, Keeler serendipitously discovered the so-called rodless mouse, which is now known to be the result of a mutation in the PDEGB gene. The historical name for the mouse strain is rd. This same defect was reported in human patients with retinitis pigmentosa in 1993. Keeler's mouse model is still used in gene therapy studies seeking to cure retinitis pigmentosa.

UR - http://www.scopus.com/inward/record.url?scp=85071067636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071067636&partnerID=8YFLogxK

U2 - 10.1016/j.oret.2019.04.019

DO - 10.1016/j.oret.2019.04.019

M3 - Article

VL - 3

SP - 716

EP - 723

JO - Ophthalmology Retina

JF - Ophthalmology Retina

SN - 2468-7219

IS - 9

ER -