Abstract
Purpose: To report the lifetime activities and accomplishments of Clyde E. Keeler (1900–1994), a pioneer in the study of retinal genetics. Design: Retrospective review. Methods: Assessment of published and unpublished biographical material. Results: Nearly a century ago, Keeler discovered an inherited abnormality in the mouse that causes the absence of rod photoreceptors and is the mouse counterpart of 1 type of human retinitis pigmentosa. Conclusions: In 1923, Keeler serendipitously discovered the so-called rodless mouse, which is now known to be the result of a mutation in the PDEGB gene. The historical name for the mouse strain is rd. This same defect was reported in human patients with retinitis pigmentosa in 1993. Keeler's mouse model is still used in gene therapy studies seeking to cure retinitis pigmentosa.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 716-723 |
| Number of pages | 8 |
| Journal | Ophthalmology Retina |
| Volume | 3 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2019 |
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ASJC Scopus subject areas
- Ophthalmology
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Clyde E. Keeler : The Rodless Mouse and the Early Days of Retinal Genetic Research. / Albert, Daniel.
In: Ophthalmology Retina, Vol. 3, No. 9, 01.09.2019, p. 716-723.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clyde E. Keeler
T2 - The Rodless Mouse and the Early Days of Retinal Genetic Research
AU - Albert, Daniel
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Purpose: To report the lifetime activities and accomplishments of Clyde E. Keeler (1900–1994), a pioneer in the study of retinal genetics. Design: Retrospective review. Methods: Assessment of published and unpublished biographical material. Results: Nearly a century ago, Keeler discovered an inherited abnormality in the mouse that causes the absence of rod photoreceptors and is the mouse counterpart of 1 type of human retinitis pigmentosa. Conclusions: In 1923, Keeler serendipitously discovered the so-called rodless mouse, which is now known to be the result of a mutation in the PDEGB gene. The historical name for the mouse strain is rd. This same defect was reported in human patients with retinitis pigmentosa in 1993. Keeler's mouse model is still used in gene therapy studies seeking to cure retinitis pigmentosa.
AB - Purpose: To report the lifetime activities and accomplishments of Clyde E. Keeler (1900–1994), a pioneer in the study of retinal genetics. Design: Retrospective review. Methods: Assessment of published and unpublished biographical material. Results: Nearly a century ago, Keeler discovered an inherited abnormality in the mouse that causes the absence of rod photoreceptors and is the mouse counterpart of 1 type of human retinitis pigmentosa. Conclusions: In 1923, Keeler serendipitously discovered the so-called rodless mouse, which is now known to be the result of a mutation in the PDEGB gene. The historical name for the mouse strain is rd. This same defect was reported in human patients with retinitis pigmentosa in 1993. Keeler's mouse model is still used in gene therapy studies seeking to cure retinitis pigmentosa.
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U2 - 10.1016/j.oret.2019.04.019
DO - 10.1016/j.oret.2019.04.019
M3 - Article
VL - 3
SP - 716
EP - 723
JO - Ophthalmology Retina
JF - Ophthalmology Retina
SN - 2468-7219
IS - 9
ER -