Clusterin

a role in cell survival in the face of apoptosis?

C. Koch-Brandt, Catherine Morgans

Research output: Contribution to journalReview article

105 Citations (Scopus)

Abstract

Clusterin is a multifunctional glycoprotein complex found in virtually all body fluids and on the surface of cells lining body cavities. Demonstrated and proposed functions include the transport of lipoproteins, the inhibition of complement-mediated cell lysis and the modulation of cell-cell interactions. On the basis of its elevated expression in apoptotic tissues, it was originally proposed that the protein might be casually involved in apoptosis. Here, we discuss the recent data that, in contrast to the earlier notion, suggest that clusterin expression is not enhanced, but rather is down-regulated in the cells undergoing apoptosis and that its expression in the apoptotic tissue is restricted to the vital neighboring cells. These results led to the proposal that rather than being a cell death gene, clusterin is a cell survival gene, exerting a protective function on the surviving bystander cells.

Original languageEnglish (US)
Pages (from-to)130-149
Number of pages20
JournalProgress in molecular and subcellular biology
Volume16
StatePublished - Dec 1 1996
Externally publishedYes

Fingerprint

Clusterin
Cell Survival
Apoptosis
Body Fluids
Cell Communication
Genes
Lipoproteins
Glycoproteins
Cell Death
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clusterin : a role in cell survival in the face of apoptosis? / Koch-Brandt, C.; Morgans, Catherine.

In: Progress in molecular and subcellular biology, Vol. 16, 01.12.1996, p. 130-149.

Research output: Contribution to journalReview article

@article{48331344747646bbbb8efee0d54bb3a4,
title = "Clusterin: a role in cell survival in the face of apoptosis?",
abstract = "Clusterin is a multifunctional glycoprotein complex found in virtually all body fluids and on the surface of cells lining body cavities. Demonstrated and proposed functions include the transport of lipoproteins, the inhibition of complement-mediated cell lysis and the modulation of cell-cell interactions. On the basis of its elevated expression in apoptotic tissues, it was originally proposed that the protein might be casually involved in apoptosis. Here, we discuss the recent data that, in contrast to the earlier notion, suggest that clusterin expression is not enhanced, but rather is down-regulated in the cells undergoing apoptosis and that its expression in the apoptotic tissue is restricted to the vital neighboring cells. These results led to the proposal that rather than being a cell death gene, clusterin is a cell survival gene, exerting a protective function on the surviving bystander cells.",
author = "C. Koch-Brandt and Catherine Morgans",
year = "1996",
month = "12",
day = "1",
language = "English (US)",
volume = "16",
pages = "130--149",
journal = "Progress in molecular and subcellular biology",
issn = "0079-6484",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Clusterin

T2 - a role in cell survival in the face of apoptosis?

AU - Koch-Brandt, C.

AU - Morgans, Catherine

PY - 1996/12/1

Y1 - 1996/12/1

N2 - Clusterin is a multifunctional glycoprotein complex found in virtually all body fluids and on the surface of cells lining body cavities. Demonstrated and proposed functions include the transport of lipoproteins, the inhibition of complement-mediated cell lysis and the modulation of cell-cell interactions. On the basis of its elevated expression in apoptotic tissues, it was originally proposed that the protein might be casually involved in apoptosis. Here, we discuss the recent data that, in contrast to the earlier notion, suggest that clusterin expression is not enhanced, but rather is down-regulated in the cells undergoing apoptosis and that its expression in the apoptotic tissue is restricted to the vital neighboring cells. These results led to the proposal that rather than being a cell death gene, clusterin is a cell survival gene, exerting a protective function on the surviving bystander cells.

AB - Clusterin is a multifunctional glycoprotein complex found in virtually all body fluids and on the surface of cells lining body cavities. Demonstrated and proposed functions include the transport of lipoproteins, the inhibition of complement-mediated cell lysis and the modulation of cell-cell interactions. On the basis of its elevated expression in apoptotic tissues, it was originally proposed that the protein might be casually involved in apoptosis. Here, we discuss the recent data that, in contrast to the earlier notion, suggest that clusterin expression is not enhanced, but rather is down-regulated in the cells undergoing apoptosis and that its expression in the apoptotic tissue is restricted to the vital neighboring cells. These results led to the proposal that rather than being a cell death gene, clusterin is a cell survival gene, exerting a protective function on the surviving bystander cells.

UR - http://www.scopus.com/inward/record.url?scp=0030348155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030348155&partnerID=8YFLogxK

M3 - Review article

VL - 16

SP - 130

EP - 149

JO - Progress in molecular and subcellular biology

JF - Progress in molecular and subcellular biology

SN - 0079-6484

ER -