TY - JOUR
T1 - Clozapine preferentially increases dopamine release in the rhesus monkey prefrontal cortex compared with the caudate nucleus
AU - Youngren, Kenneth D.
AU - Inglis, Fiona M.
AU - Pivirotto, Philip J.
AU - Jedema, Hank P.
AU - Bradberry, Charles W.
AU - Goldman-Rakic, Patricia S.
AU - Roth, Robert H.
AU - Moghaddam, Bita
PY - 1999/5
Y1 - 1999/5
N2 - Despite substantial differences between species in the organization and elaboration of the cortical dopamine innervation, little is known about the pharmacological response of cortical or striatal sites to antipsychotic medications in nonhuman primates. To examine this issue, rhesus monkeys were chronically implanted with guide cannulae directed at the principal sulcus, medial prefrontal cortex, premotor cortex, and caudate nucleus. Alterations in dopamine release in these discrete brain regions were measured in response to administration of clozapine or haloperidol. Clozapine produced significant and long-lasting increases in dopamine release in the principal sulcus, and to a lesser extent, in the caudate nucleus. Haloperidol did not produce a consistent effect on dopamine release in the principal sulcus, although it increased dopamine release in the caudate. Clozapine's preferential augmentation of dopamine release in the dorsolateral prefrontal cortex supports the idea that clozapine exerts its therapeutic effects in part by increasing cortical dopamine neurotransmission. Copyright (C) 1999 American College of Neuropsychopharmacology.
AB - Despite substantial differences between species in the organization and elaboration of the cortical dopamine innervation, little is known about the pharmacological response of cortical or striatal sites to antipsychotic medications in nonhuman primates. To examine this issue, rhesus monkeys were chronically implanted with guide cannulae directed at the principal sulcus, medial prefrontal cortex, premotor cortex, and caudate nucleus. Alterations in dopamine release in these discrete brain regions were measured in response to administration of clozapine or haloperidol. Clozapine produced significant and long-lasting increases in dopamine release in the principal sulcus, and to a lesser extent, in the caudate nucleus. Haloperidol did not produce a consistent effect on dopamine release in the principal sulcus, although it increased dopamine release in the caudate. Clozapine's preferential augmentation of dopamine release in the dorsolateral prefrontal cortex supports the idea that clozapine exerts its therapeutic effects in part by increasing cortical dopamine neurotransmission. Copyright (C) 1999 American College of Neuropsychopharmacology.
KW - Antipsychotic drugs
KW - Haloperidol
KW - Microdialysis
KW - Schizophrenia
KW - Striatum
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U2 - 10.1016/S0893-133X(98)00082-7
DO - 10.1016/S0893-133X(98)00082-7
M3 - Article
C2 - 10192821
AN - SCOPUS:0033136167
SN - 0893-133X
VL - 20
SP - 403
EP - 412
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 5
ER -