Closure of laryngectomy defects in the age of chemoradiation therapy

Matthew M. Hanasono, Derrick Lin, Mark Wax, Eben L. Rosenthal

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The use of chemoradiation therapy in laryngeal cancer has resulted in significant reconstructive challenges. Although reconstruction of salvage laryngectomy defects remains controversial, current literature supports aggressive management of these defects with vascularized tissue, even when there is sufficient pharyngeal tissue present for primary closure. Significant advancement in reconstructive techniques has permitted improved outcomes in patients with advanced disease who require total laryngopharyngectomy or total laryngoglossectomy. Use of enteric and fasciocutaneous flaps result in good patient outcomes. Finally, wound complication rates after salvage surgery approach 60% depending on comorbid conditions such as cardiac insufficiency, hypothyroidism, or extent of previous treatment. Neck dehiscence, great vessel exposure, fistula formation, or cervical skin necrosis results in complex wounds that can often be treated initially with negative pressure dressings followed by definitive reconstruction. The timing of repair and approach to the vessel-depleted neck also present challenges in this patient population. Currently, there is significant institutional bias in the management of the patient with postchemoradiation salvage laryngectomy. Future prospective multi-institutional studies are certainly needed to more clearly define optimal treatment of these difficult patients.

Original languageEnglish (US)
Pages (from-to)580-588
Number of pages9
JournalHead and Neck
Volume34
Issue number4
DOIs
StatePublished - Apr 2012

Fingerprint

Laryngectomy
Neck
Negative-Pressure Wound Therapy
Therapeutics
Laryngeal Neoplasms
Wounds and Injuries
Hypothyroidism
Fistula
Necrosis
Skin
Population

Keywords

  • free flap
  • head and neck cancer
  • laryngectomy
  • salvage surgery
  • wound complications

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Closure of laryngectomy defects in the age of chemoradiation therapy. / Hanasono, Matthew M.; Lin, Derrick; Wax, Mark; Rosenthal, Eben L.

In: Head and Neck, Vol. 34, No. 4, 04.2012, p. 580-588.

Research output: Contribution to journalArticle

Hanasono, Matthew M. ; Lin, Derrick ; Wax, Mark ; Rosenthal, Eben L. / Closure of laryngectomy defects in the age of chemoradiation therapy. In: Head and Neck. 2012 ; Vol. 34, No. 4. pp. 580-588.
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