Clostridial myonecrosis cluster among injection drug users: A molecular epidemiology investigation

David Bangsberg, Judith L. Rosen, Tomás Aragón, Andre Campbell, Lucy Weir, Francoise Perdreau-Remington

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A molecular epidemiologic investigation was performed on a cluster of severe necrotizing Clostridium infections in 5 injection drug users admitted to an urban community hospital. Interviews with survivors suggested a point source of infection. Pulsed-field gel electrophoresis of SmaI restriction digests was performed to determine the molecular relatedness of clinically obtained isolates and isolates obtained from heroin samples and the home environment. A common clonal strain was found in Clostridium sordellii isolates from 2 socially unrelated patients and from drug paraphernalia. Clonality of a Clostridium perfringens strain from another patient isolate was identical to an isolate from a syringe found in her home. Other C perfringens isolates from patients, heroin, and the environment were determined to be polyclonal. We postulate that rapid recognition and public health notification led to rapid resolution of the outbreak.

Original languageEnglish (US)
Pages (from-to)517-522
Number of pages6
JournalArchives of Internal Medicine
Volume162
Issue number5
StatePublished - 2002
Externally publishedYes

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Molecular Epidemiology
Drug Users
Heroin
Injections
Clostridium sordellii
Clostridium Infections
Clostridium perfringens
Pulsed Field Gel Electrophoresis
Urban Hospitals
Community Hospital
Syringes
Disease Outbreaks
Survivors
Public Health
Interviews
Infection
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Bangsberg, D., Rosen, J. L., Aragón, T., Campbell, A., Weir, L., & Perdreau-Remington, F. (2002). Clostridial myonecrosis cluster among injection drug users: A molecular epidemiology investigation. Archives of Internal Medicine, 162(5), 517-522.

Clostridial myonecrosis cluster among injection drug users : A molecular epidemiology investigation. / Bangsberg, David; Rosen, Judith L.; Aragón, Tomás; Campbell, Andre; Weir, Lucy; Perdreau-Remington, Francoise.

In: Archives of Internal Medicine, Vol. 162, No. 5, 2002, p. 517-522.

Research output: Contribution to journalArticle

Bangsberg, D, Rosen, JL, Aragón, T, Campbell, A, Weir, L & Perdreau-Remington, F 2002, 'Clostridial myonecrosis cluster among injection drug users: A molecular epidemiology investigation', Archives of Internal Medicine, vol. 162, no. 5, pp. 517-522.
Bangsberg, David ; Rosen, Judith L. ; Aragón, Tomás ; Campbell, Andre ; Weir, Lucy ; Perdreau-Remington, Francoise. / Clostridial myonecrosis cluster among injection drug users : A molecular epidemiology investigation. In: Archives of Internal Medicine. 2002 ; Vol. 162, No. 5. pp. 517-522.
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