Abstract
Dental caries characterized by acid damage of tooth enamel is a persistent disease that begins with the formation of biofilms on the tooth surface. The secreted glucosyltransferases enable Streptococcus mutans to synthesize extracellular glucan polymers using ingested starch within the oral cavity, which eventually results in the production of acid, a contributing factor to cariogenesis. In this paper, we report the cloning, expression, purification, crystallization, and preliminary X-ray diffraction characterization of glucosyltransferase B.
Original language | English (US) |
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Journal | Natural Product Communications |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - May 2019 |
Externally published | Yes |
Keywords
- Biofilm
- Dental caries
- Glucans
- Glucosyltransferase
ASJC Scopus subject areas
- Drug Discovery
- Complementary and alternative medicine
- Plant Science
- Pharmacology