Cloning and Characterization of a Human cDNA (INPPL1) Sharing Homology with Inositol Polyphosphate Phosphatases

James A. Hejna, Hiroshi Saito, Louise S. Merkens, Thomas V. Tittle, Petra M. Jakobs, Michael A. Whitney, Markus Grompe, Andrew S. Friedberg, Robb Moses

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We have cloned a novel human cDNA, INPPL1 (GenBank Accession No. L36818), which maps to 11q23. The corresponding mRNA is 4657 nt in length and is widely expressed in both fetal and adult tissues. An open reading frame of 3441 nt encodes a putative polypeptide that shares several domains with inositol triphosphate phosphatases. Several polymorphisms have been mapped to the 3′-untranslated region, yet the putative coding region showed no polymorphisms in nine independent cDNA samples.

Original languageEnglish (US)
Pages (from-to)285-287
Number of pages3
JournalGenomics
Volume29
Issue number1
DOIs
StatePublished - Sep 1 1995

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Polyphosphates
Organism Cloning
Complementary DNA
Nucleic Acid Databases
3' Untranslated Regions
Open Reading Frames
Fetus
Messenger RNA
Peptides
myo-inositol-1 (or 4)-monophosphatase
inositol triphosphate phosphomonoesterase

ASJC Scopus subject areas

  • Genetics

Cite this

Cloning and Characterization of a Human cDNA (INPPL1) Sharing Homology with Inositol Polyphosphate Phosphatases. / Hejna, James A.; Saito, Hiroshi; Merkens, Louise S.; Tittle, Thomas V.; Jakobs, Petra M.; Whitney, Michael A.; Grompe, Markus; Friedberg, Andrew S.; Moses, Robb.

In: Genomics, Vol. 29, No. 1, 01.09.1995, p. 285-287.

Research output: Contribution to journalArticle

Hejna, JA, Saito, H, Merkens, LS, Tittle, TV, Jakobs, PM, Whitney, MA, Grompe, M, Friedberg, AS & Moses, R 1995, 'Cloning and Characterization of a Human cDNA (INPPL1) Sharing Homology with Inositol Polyphosphate Phosphatases', Genomics, vol. 29, no. 1, pp. 285-287. https://doi.org/10.1006/geno.1995.1247
Hejna, James A. ; Saito, Hiroshi ; Merkens, Louise S. ; Tittle, Thomas V. ; Jakobs, Petra M. ; Whitney, Michael A. ; Grompe, Markus ; Friedberg, Andrew S. ; Moses, Robb. / Cloning and Characterization of a Human cDNA (INPPL1) Sharing Homology with Inositol Polyphosphate Phosphatases. In: Genomics. 1995 ; Vol. 29, No. 1. pp. 285-287.
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