Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib

Marc Loriaux, Michael Deininger

Research output: Contribution to journalReview article

61 Scopus citations

Abstract

Treatment of chronic myeloid leukemia (CML) with imatinib (Gleevec®) induces a much higher rate of partial and complete cytogenetic responses (CCR) than interferon-α (IFN)-based therapies. Conventional wisdom suggests that elimination of the Philadelphia (Ph)- positive cells will lead to re-establishment of normal Ph-negative hematopoiesis. Surprisingly, karyotypic abnormalities were detected in the chromosome negative cells of some patients with cytogenetic response to imatinib. In some cases, this was associated with a myelodysplastic syndrome (MDS). While clonal evolution in Ph-positive cells is considered part of the progression of CML, clonal evolution in Ph-negative cells had been observed only rarely in a small number of patients treated with IFN or bone marrow transplantation, raising the question whether the phenomenon may be causally linked to imatinib therapy. In this manuscript, we will review the currently available data, suggest possible causes and discuss potential implications for patient management. We are fully aware that a systematic study of a larger patient cohort will be required to conclusively address these issues.

Original languageEnglish (US)
Pages (from-to)2197-2203
Number of pages7
JournalLeukemia and Lymphoma
Volume45
Issue number11
DOIs
StatePublished - Nov 1 2004

Keywords

  • Chronic myelogenous leukemia
  • Clonal evolution
  • Imatinib mesylate
  • Philadelphia-negative hematopoiesis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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