Clinics of ocular tuberculosis

Vishali Gupta, Samir S. Shoughy, Sarakshi Mahajan, Moncef Khairallah, James T. Rosenbaum, Andre Curi, Khalid F. Tabbara

Research output: Contribution to journalReview article

68 Scopus citations

Abstract

Purpose: Ocular tuberculosis is an extrapulmonary tuberculous condition and has variable manifestations. The purpose of this review is to describe the clinical manifestations of ocular tuberculosis affecting the anterior and posterior segments of the eye in both immunocompetent and immunocompromised patients. Methods : Review of literature using Pubmed database. Results: Mycobacterium tuberculosis may lead to formation of conjunctival granuloma, nodular scleritis, and interstitial keratitis. Lacrimal gland and orbital caseating granulomas are rare but may occur. The intraocular structures are also a target of insult by M. tuberculosis and may cause anterior granulomatous uveitis, anterior and posterior synechiae, secondary glaucoma, and cataract. The bacillus may involve the ciliary body, resulting in the formation of a localized caseating granuloma. Posterior segment manifestations include vitritis, retinal vasculitis, optic neuritis, serpiginous-like choroiditis, choroidal tubercules, subretinal neovascularization, and, rarely, endophthalmitis. Conclusions: The recognition of clinical signs of ocular tuberculosis is of utmost importance as it can provide clinical pathway toward tailored investigations and decision making for initiating anti-tuberculosis therapy.

Original languageEnglish (US)
Pages (from-to)14-24
Number of pages11
JournalOcular Immunology and Inflammation
Volume23
Issue number1
DOIs
StatePublished - Feb 1 2015

Keywords

  • Anterior granulomatous uveitis
  • Intermediate uveitis
  • Ocular tuberculosis
  • Posterior uveitis
  • Scleritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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  • Cite this

    Gupta, V., Shoughy, S. S., Mahajan, S., Khairallah, M., Rosenbaum, J. T., Curi, A., & Tabbara, K. F. (2015). Clinics of ocular tuberculosis. Ocular Immunology and Inflammation, 23(1), 14-24. https://doi.org/10.3109/09273948.2014.986582