Clinicopathological study of clear-cell tumors of the thyroid

An evaluation of 22 cases

Kazuo Shimizu, Mitsuji Nagahama, Yutaka Kitamura, Kwang-Yung Chin, Wataru Kitagawa, Tetsuo Shibuya, Takashi Mimura, Osamu Ozaki, Kiminori Sugino, Kunihiko Ito, Shigeo Tanaka

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Twenty-two cases of partial or wholly composed clear-cell thyroid tumors were reviewed to differentiate between a primary nodule and metastatic clear-cell renal carcinoma in the thyroid. Pathological reevaluation of HE-stained specimens, immunohistochemical observation using anti-thyroglobulin (TG) antibody, and periodic acid-Schiff (PAS) staining were performed. The pathological characteristics in metastases from the kidney have a greater tendency to demonstrate a strikingly clear cytoplasm with small nuclei, rich vascularization, and a trabecular arrangement of tumor cells than do primary thyroid cases. The immunohistochemical TG staining in conjunction with PAS staining for the recognition of follicular colloid could provide much more reliable information of primary cases compared to that using TG staining alone. Clinically, in primary cases, the female: male ratio is substantially higher while the mean age is lower than in metastatic cases reflecting differentiated thyroid carcinoma. In conclusion, immunohistochemical staining for TG with PAS staining for the recognition of follicular colloid proved to be the most sensitive method for identifying primary clear cell thyroid tumors. In addition, a careful assessment of past and/or present kidney disorders to rule out metastatic renal cell carcinoma is advisable. Age, gender, and physiological findings are also informative when differentiating between them.

Original languageEnglish (US)
Pages (from-to)1015-1022
Number of pages8
JournalSurgery Today
Volume25
Issue number12
DOIs
StatePublished - Dec 1995
Externally publishedYes

Fingerprint

Thyroid Gland
Staining and Labeling
Periodic Acid
Thyroglobulin
Neoplasms
Colloids
Renal Cell Carcinoma
Kidney
Thyroid Neoplasms
Cytoplasm
Observation
Neoplasm Metastasis

Keywords

  • clear-cell tumor
  • metastatic clear-cell carcinoma
  • renal cell carcinoma
  • thyroid

ASJC Scopus subject areas

  • Surgery

Cite this

Shimizu, K., Nagahama, M., Kitamura, Y., Chin, K-Y., Kitagawa, W., Shibuya, T., ... Tanaka, S. (1995). Clinicopathological study of clear-cell tumors of the thyroid: An evaluation of 22 cases. Surgery Today, 25(12), 1015-1022. https://doi.org/10.1007/BF00311685

Clinicopathological study of clear-cell tumors of the thyroid : An evaluation of 22 cases. / Shimizu, Kazuo; Nagahama, Mitsuji; Kitamura, Yutaka; Chin, Kwang-Yung; Kitagawa, Wataru; Shibuya, Tetsuo; Mimura, Takashi; Ozaki, Osamu; Sugino, Kiminori; Ito, Kunihiko; Tanaka, Shigeo.

In: Surgery Today, Vol. 25, No. 12, 12.1995, p. 1015-1022.

Research output: Contribution to journalArticle

Shimizu, K, Nagahama, M, Kitamura, Y, Chin, K-Y, Kitagawa, W, Shibuya, T, Mimura, T, Ozaki, O, Sugino, K, Ito, K & Tanaka, S 1995, 'Clinicopathological study of clear-cell tumors of the thyroid: An evaluation of 22 cases', Surgery Today, vol. 25, no. 12, pp. 1015-1022. https://doi.org/10.1007/BF00311685
Shimizu, Kazuo ; Nagahama, Mitsuji ; Kitamura, Yutaka ; Chin, Kwang-Yung ; Kitagawa, Wataru ; Shibuya, Tetsuo ; Mimura, Takashi ; Ozaki, Osamu ; Sugino, Kiminori ; Ito, Kunihiko ; Tanaka, Shigeo. / Clinicopathological study of clear-cell tumors of the thyroid : An evaluation of 22 cases. In: Surgery Today. 1995 ; Vol. 25, No. 12. pp. 1015-1022.
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