Clinicopathological and molecular features of myeloid sarcoma as initial presentation of therapy-related myeloid neoplasms: a single institution experience

Deniz Peker, Vishwas Parekh, Ravikumar Paluri, Taylor Deal, Uma Borate, Antonio Di Stasi, Shuko Harada, Emmanuel Agosto Arroyo, Vishnu Reddy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Therapy-related myeloid neoplasms (t-MN) have a common origin in prior cytotoxic therapy and/or radiation. These neoplasms include therapy-related acute myeloid leukemia, myelodysplastic syndrome (t-MDS), and myelodysplastic/myeloproliferative neoplasms (t-MDS/MPN). Myeloid sarcoma (MS), on the other hand, is a rare disease manifesting as an extramedullary collection of immature cells of myeloid lineage. Rarer still is therapy-related MS (t-MS), which has not been adequately studied due to its rarity and its lack of recognition as a unique entity among other t-MN. Here, we report what is to our knowledge the first case series of t-MS, with the aim of investigating and establishing salient clinicopathological and molecular features of this entity.

Original languageEnglish (US)
Pages (from-to)457-463
Number of pages7
JournalInternational Journal of Hematology
Volume100
Issue number5
DOIs
StatePublished - 2014
Externally publishedYes

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Myeloid Sarcoma
Second Primary Neoplasms
Myelodysplastic Syndromes
Cell Lineage
Rare Diseases
Acute Myeloid Leukemia
Radiotherapy
Therapeutics
Neoplasms

Keywords

  • Acute myeloid leukemia
  • Myeloid sarcoma
  • Therapy-related myeloid neoplasms

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

Clinicopathological and molecular features of myeloid sarcoma as initial presentation of therapy-related myeloid neoplasms : a single institution experience. / Peker, Deniz; Parekh, Vishwas; Paluri, Ravikumar; Deal, Taylor; Borate, Uma; Di Stasi, Antonio; Harada, Shuko; Arroyo, Emmanuel Agosto; Reddy, Vishnu.

In: International Journal of Hematology, Vol. 100, No. 5, 2014, p. 457-463.

Research output: Contribution to journalArticle

Peker, Deniz ; Parekh, Vishwas ; Paluri, Ravikumar ; Deal, Taylor ; Borate, Uma ; Di Stasi, Antonio ; Harada, Shuko ; Arroyo, Emmanuel Agosto ; Reddy, Vishnu. / Clinicopathological and molecular features of myeloid sarcoma as initial presentation of therapy-related myeloid neoplasms : a single institution experience. In: International Journal of Hematology. 2014 ; Vol. 100, No. 5. pp. 457-463.
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