Clinicopathological and molecular features of myeloid sarcoma as initial presentation of therapy-related myeloid neoplasms: a single institution experience

Deniz Peker, Vishwas Parekh, Ravikumar Paluri, Taylor Deal, Uma Borate, Antonio Di Stasi, Shuko Harada, Emmanuel Agosto Arroyo, Vishnu Reddy

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Therapy-related myeloid neoplasms (t-MN) have a common origin in prior cytotoxic therapy and/or radiation. These neoplasms include therapy-related acute myeloid leukemia, myelodysplastic syndrome (t-MDS), and myelodysplastic/myeloproliferative neoplasms (t-MDS/MPN). Myeloid sarcoma (MS), on the other hand, is a rare disease manifesting as an extramedullary collection of immature cells of myeloid lineage. Rarer still is therapy-related MS (t-MS), which has not been adequately studied due to its rarity and its lack of recognition as a unique entity among other t-MN. Here, we report what is to our knowledge the first case series of t-MS, with the aim of investigating and establishing salient clinicopathological and molecular features of this entity.

Original languageEnglish (US)
Pages (from-to)457-463
Number of pages7
JournalInternational Journal of Hematology
Volume100
Issue number5
DOIs
StatePublished - Nov 2014
Externally publishedYes

Keywords

  • Acute myeloid leukemia
  • Myeloid sarcoma
  • Therapy-related myeloid neoplasms

ASJC Scopus subject areas

  • Hematology

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