TY - JOUR
T1 - Clinicopathological and molecular features of myeloid sarcoma as initial presentation of therapy-related myeloid neoplasms
T2 - a single institution experience
AU - Peker, Deniz
AU - Parekh, Vishwas
AU - Paluri, Ravikumar
AU - Deal, Taylor
AU - Borate, Uma
AU - Di Stasi, Antonio
AU - Harada, Shuko
AU - Arroyo, Emmanuel Agosto
AU - Reddy, Vishnu
N1 - Publisher Copyright:
© 2014, The Japanese Society of Hematology.
PY - 2014/11
Y1 - 2014/11
N2 - Therapy-related myeloid neoplasms (t-MN) have a common origin in prior cytotoxic therapy and/or radiation. These neoplasms include therapy-related acute myeloid leukemia, myelodysplastic syndrome (t-MDS), and myelodysplastic/myeloproliferative neoplasms (t-MDS/MPN). Myeloid sarcoma (MS), on the other hand, is a rare disease manifesting as an extramedullary collection of immature cells of myeloid lineage. Rarer still is therapy-related MS (t-MS), which has not been adequately studied due to its rarity and its lack of recognition as a unique entity among other t-MN. Here, we report what is to our knowledge the first case series of t-MS, with the aim of investigating and establishing salient clinicopathological and molecular features of this entity.
AB - Therapy-related myeloid neoplasms (t-MN) have a common origin in prior cytotoxic therapy and/or radiation. These neoplasms include therapy-related acute myeloid leukemia, myelodysplastic syndrome (t-MDS), and myelodysplastic/myeloproliferative neoplasms (t-MDS/MPN). Myeloid sarcoma (MS), on the other hand, is a rare disease manifesting as an extramedullary collection of immature cells of myeloid lineage. Rarer still is therapy-related MS (t-MS), which has not been adequately studied due to its rarity and its lack of recognition as a unique entity among other t-MN. Here, we report what is to our knowledge the first case series of t-MS, with the aim of investigating and establishing salient clinicopathological and molecular features of this entity.
KW - Acute myeloid leukemia
KW - Myeloid sarcoma
KW - Therapy-related myeloid neoplasms
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U2 - 10.1007/s12185-014-1659-y
DO - 10.1007/s12185-014-1659-y
M3 - Article
C2 - 25209604
AN - SCOPUS:84919949135
SN - 0925-5710
VL - 100
SP - 457
EP - 463
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 5
ER -