Clinicopathologic correlation of fluorescein and indocyanine green videoangiography in occult choroidal neovascularization

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Abstract

Purpose: To correlate the histopalhologic features of a postmortem eye with fluorescein and indocyanine green (ICG) angiography performed to evaluate recurrent occult choroidal neovascularization (CNV). Methods: Histopathologic features from serial sections through the macula of a 76 year old man with recurrent occult CNV were reconstructed in a scaled two dimensional map and overlaid on fluorescein and ICG angiogram images obtained four months prior to his death Results: Choroidal fibrosis and absent choriocapillaris in the region of prior laser photocoagulation corresponded to a well demarcated hypofluorescent region in the early frames of the fluorescein angiogram and the early and late phases of the ICG angiogram A thin predominantly intra-Bruch's fibrovascular membrane corresponded to stippled late hyperfluorescence on the fluorescein angiogram and to mild late hyperfluorescence on the ICG angiogram Adjacent to the region of prior laser photocoagulation, thick intra-Bruch's and sub-retinal fibrovascular complexes contained a high density of vessels and basophilic extracellular matrix and corresponded to elevated late hyperfluorescence on the fluorescein angiogram and intense late hyperfluorescence on the ICG angiogram Conclusion: Histopathologic mapping revealed a larger than expected fibrovascular complex within Bruch's membrane which correlated well with findings on fluorescein and ICG angiography.

Original languageEnglish (US)
JournalInvestigative Ophthalmology and Visual Science
Volume38
Issue number4
StatePublished - 1997

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Choroidal Neovascularization
Indocyanine Green
Fluorescein
Angiography
Bruch Membrane
Light Coagulation
Lasers
Extracellular Matrix
Fibrosis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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title = "Clinicopathologic correlation of fluorescein and indocyanine green videoangiography in occult choroidal neovascularization",
abstract = "Purpose: To correlate the histopalhologic features of a postmortem eye with fluorescein and indocyanine green (ICG) angiography performed to evaluate recurrent occult choroidal neovascularization (CNV). Methods: Histopathologic features from serial sections through the macula of a 76 year old man with recurrent occult CNV were reconstructed in a scaled two dimensional map and overlaid on fluorescein and ICG angiogram images obtained four months prior to his death Results: Choroidal fibrosis and absent choriocapillaris in the region of prior laser photocoagulation corresponded to a well demarcated hypofluorescent region in the early frames of the fluorescein angiogram and the early and late phases of the ICG angiogram A thin predominantly intra-Bruch's fibrovascular membrane corresponded to stippled late hyperfluorescence on the fluorescein angiogram and to mild late hyperfluorescence on the ICG angiogram Adjacent to the region of prior laser photocoagulation, thick intra-Bruch's and sub-retinal fibrovascular complexes contained a high density of vessels and basophilic extracellular matrix and corresponded to elevated late hyperfluorescence on the fluorescein angiogram and intense late hyperfluorescence on the ICG angiogram Conclusion: Histopathologic mapping revealed a larger than expected fibrovascular complex within Bruch's membrane which correlated well with findings on fluorescein and ICG angiography.",
author = "Lauer, {Andreas (Andy)} and David Wilson and Michael Klein",
year = "1997",
language = "English (US)",
volume = "38",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "4",

}

TY - JOUR

T1 - Clinicopathologic correlation of fluorescein and indocyanine green videoangiography in occult choroidal neovascularization

AU - Lauer, Andreas (Andy)

AU - Wilson, David

AU - Klein, Michael

PY - 1997

Y1 - 1997

N2 - Purpose: To correlate the histopalhologic features of a postmortem eye with fluorescein and indocyanine green (ICG) angiography performed to evaluate recurrent occult choroidal neovascularization (CNV). Methods: Histopathologic features from serial sections through the macula of a 76 year old man with recurrent occult CNV were reconstructed in a scaled two dimensional map and overlaid on fluorescein and ICG angiogram images obtained four months prior to his death Results: Choroidal fibrosis and absent choriocapillaris in the region of prior laser photocoagulation corresponded to a well demarcated hypofluorescent region in the early frames of the fluorescein angiogram and the early and late phases of the ICG angiogram A thin predominantly intra-Bruch's fibrovascular membrane corresponded to stippled late hyperfluorescence on the fluorescein angiogram and to mild late hyperfluorescence on the ICG angiogram Adjacent to the region of prior laser photocoagulation, thick intra-Bruch's and sub-retinal fibrovascular complexes contained a high density of vessels and basophilic extracellular matrix and corresponded to elevated late hyperfluorescence on the fluorescein angiogram and intense late hyperfluorescence on the ICG angiogram Conclusion: Histopathologic mapping revealed a larger than expected fibrovascular complex within Bruch's membrane which correlated well with findings on fluorescein and ICG angiography.

AB - Purpose: To correlate the histopalhologic features of a postmortem eye with fluorescein and indocyanine green (ICG) angiography performed to evaluate recurrent occult choroidal neovascularization (CNV). Methods: Histopathologic features from serial sections through the macula of a 76 year old man with recurrent occult CNV were reconstructed in a scaled two dimensional map and overlaid on fluorescein and ICG angiogram images obtained four months prior to his death Results: Choroidal fibrosis and absent choriocapillaris in the region of prior laser photocoagulation corresponded to a well demarcated hypofluorescent region in the early frames of the fluorescein angiogram and the early and late phases of the ICG angiogram A thin predominantly intra-Bruch's fibrovascular membrane corresponded to stippled late hyperfluorescence on the fluorescein angiogram and to mild late hyperfluorescence on the ICG angiogram Adjacent to the region of prior laser photocoagulation, thick intra-Bruch's and sub-retinal fibrovascular complexes contained a high density of vessels and basophilic extracellular matrix and corresponded to elevated late hyperfluorescence on the fluorescein angiogram and intense late hyperfluorescence on the ICG angiogram Conclusion: Histopathologic mapping revealed a larger than expected fibrovascular complex within Bruch's membrane which correlated well with findings on fluorescein and ICG angiography.

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