Clinically silent progressive renal tubulointerstitial disease during cisplatin chemotherapy

D. G. Guinee, B. Van Zee, Donald Houghton

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background. Chronic cisplatin nephrotoxicity is well documented in animal models but not well characterized in humans. The authors report a 56-year- old woman who had end-stage chronic tubulointerstitial nephropathy develop during treatment with multiple courses of cisplatin chemotherapy for ovarian carcinoma. Methods. A biopsy was performed to determine the etiology of renal failure, and the morphologic, immunofluorescent, and ultrastructural findings are reported. The clinical history and morphologic findings were analyzed to identify possible causes, other than cisplatin, of chronic renal disease. Results. Morphologic studies showed extensive renal tubulointerstitial fibrosis with relative sparing of glomeruli. Conclusions. Profound, progressive renal injury occurred during cisplatin treatment despite adherence to treatment protocols designed to minimize such toxicity. Renal injury was undetected by pretreatment serum creatinine determinations. This case and others emphasize the relative insensitivity of this test for chronic renal damage during treatment with nephrotoxic drugs.

Original languageEnglish (US)
Pages (from-to)4050-4054
Number of pages5
JournalCancer
Volume71
Issue number12
StatePublished - 1993

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Cisplatin
Kidney
Drug Therapy
Wounds and Injuries
Clinical Protocols
Chronic Renal Insufficiency
Renal Insufficiency
Creatinine
Fibrosis
Therapeutics
Animal Models
Carcinoma
Biopsy
Serum
Pharmaceutical Preparations

Keywords

  • chronic renal failure
  • cisplatin
  • interstitial nephritis
  • nephrotoxicity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Clinically silent progressive renal tubulointerstitial disease during cisplatin chemotherapy. / Guinee, D. G.; Van Zee, B.; Houghton, Donald.

In: Cancer, Vol. 71, No. 12, 1993, p. 4050-4054.

Research output: Contribution to journalArticle

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