Clinically Localized Prostate Cancer: AUA/ASTRO Guideline. Part III: Principles of Radiation and Future Directions

James A. Eastham; Gregory B. Auffenberg; Daniel A. Barocas; Roger Chou; Tony Crispino; John W. Davis; Scott Eggener; Eric M. Horwitz; Christopher J. Kane; Erin Kirkby; Daniel W. Lin; Sean M. McBride; Alicia K. Morgans; Phillip M. Pierorazio; George Rodrigues; William W. Wong; Stephen A. Boorjian

doi:10.1097/JU.0000000000002759

Clinically Localized Prostate Cancer: AUA/ASTRO Guideline. Part III: Principles of Radiation and Future Directions

James A. Eastham, Gregory B. Auffenberg, Daniel A. Barocas, Roger Chou, Tony Crispino, John W. Davis, Scott Eggener, Eric M. Horwitz, Christopher J. Kane, Erin Kirkby, Daniel W. Lin, Sean M. McBride, Alicia K. Morgans, Phillip M. Pierorazio, George Rodrigues, William W. Wong, Stephen A. Boorjian

Medical Informatics and Clinical Epidemiology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Purpose:The summary presented herein represents Part III of the three-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO Guideline, discussing principles of radiation and offering several future directions of further relevant study in patients diagnosed with clinically localized prostate cancer. Please refer to Parts I and II for discussion of risk assessment, staging, and risk-based management (Part I), and principles of active surveillance and surgery and follow-up (Part II).Materials and Methods:The systematic review utilized to inform this guideline was conducted by an independent methodological consultant. A research librarian conducted searches in Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. The methodology team supplemented searches of electronic databases with the studies included in the prior AUA review and by reviewing reference lists of relevant articles.Results:The Clinically Localized Prostate Cancer Panel created evidence- and consensus-based guideline statements to aid clinicians in the management of patients with clinically localized prostate cancer. Statements regarding management of patients using radiation therapy as well as important future directions of research are detailed herein.Conclusions:This guideline aims to inform clinicians treating patients with clinically localized prostate cancer. Continued research and publication of high-quality evidence from future trials will be essential to further improve care for these men.

Original language	English (US)
Pages (from-to)	26-33
Number of pages	8
Journal	Journal of Urology
Volume	208
Issue number	1
DOIs	https://doi.org/10.1097/JU.0000000000002759
State	Published - Jul 1 2022

Keywords

Active surveillance
Prostate cancer
Radiation therapy for prostate cancer
Radical prostatectomy
Shared decision making

ASJC Scopus subject areas

Urology

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10.1097/JU.0000000000002759

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Eastham, J. A., Auffenberg, G. B., Barocas, D. A., Chou, R., Crispino, T., Davis, J. W., Eggener, S., Horwitz, E. M., Kane, C. J., Kirkby, E., Lin, D. W., McBride, S. M., Morgans, A. K., Pierorazio, P. M., Rodrigues, G., Wong, W. W., & Boorjian, S. A. (2022). Clinically Localized Prostate Cancer: AUA/ASTRO Guideline. Part III: Principles of Radiation and Future Directions. Journal of Urology, 208(1), 26-33. https://doi.org/10.1097/JU.0000000000002759

Eastham, JA, Auffenberg, GB, Barocas, DA, Chou, R, Crispino, T, Davis, JW, Eggener, S, Horwitz, EM, Kane, CJ, Kirkby, E, Lin, DW, McBride, SM, Morgans, AK, Pierorazio, PM, Rodrigues, G, Wong, WW & Boorjian, SA 2022, 'Clinically Localized Prostate Cancer: AUA/ASTRO Guideline. Part III: Principles of Radiation and Future Directions', Journal of Urology, vol. 208, no. 1, pp. 26-33. https://doi.org/10.1097/JU.0000000000002759

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abstract = "Purpose:The summary presented herein represents Part III of the three-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO Guideline, discussing principles of radiation and offering several future directions of further relevant study in patients diagnosed with clinically localized prostate cancer. Please refer to Parts I and II for discussion of risk assessment, staging, and risk-based management (Part I), and principles of active surveillance and surgery and follow-up (Part II).Materials and Methods:The systematic review utilized to inform this guideline was conducted by an independent methodological consultant. A research librarian conducted searches in Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. The methodology team supplemented searches of electronic databases with the studies included in the prior AUA review and by reviewing reference lists of relevant articles.Results:The Clinically Localized Prostate Cancer Panel created evidence- and consensus-based guideline statements to aid clinicians in the management of patients with clinically localized prostate cancer. Statements regarding management of patients using radiation therapy as well as important future directions of research are detailed herein.Conclusions:This guideline aims to inform clinicians treating patients with clinically localized prostate cancer. Continued research and publication of high-quality evidence from future trials will be essential to further improve care for these men.",

keywords = "Active surveillance, Prostate cancer, Radiation therapy for prostate cancer, Radical prostatectomy, Shared decision making",

author = "Eastham, {James A.} and Auffenberg, {Gregory B.} and Barocas, {Daniel A.} and Roger Chou and Tony Crispino and Davis, {John W.} and Scott Eggener and Horwitz, {Eric M.} and Kane, {Christopher J.} and Erin Kirkby and Lin, {Daniel W.} and McBride, {Sean M.} and Morgans, {Alicia K.} and Pierorazio, {Phillip M.} and George Rodrigues and Wong, {William W.} and Boorjian, {Stephen A.}",

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doi = "10.1097/JU.0000000000002759",

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AU - Eastham, James A.

AU - Auffenberg, Gregory B.

AU - Barocas, Daniel A.

AU - Chou, Roger

AU - Crispino, Tony

AU - Davis, John W.

AU - Eggener, Scott

AU - Horwitz, Eric M.

AU - Kane, Christopher J.

AU - Kirkby, Erin

AU - Lin, Daniel W.

AU - McBride, Sean M.

AU - Morgans, Alicia K.

AU - Pierorazio, Phillip M.

AU - Rodrigues, George

AU - Wong, William W.

AU - Boorjian, Stephen A.

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N2 - Purpose:The summary presented herein represents Part III of the three-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO Guideline, discussing principles of radiation and offering several future directions of further relevant study in patients diagnosed with clinically localized prostate cancer. Please refer to Parts I and II for discussion of risk assessment, staging, and risk-based management (Part I), and principles of active surveillance and surgery and follow-up (Part II).Materials and Methods:The systematic review utilized to inform this guideline was conducted by an independent methodological consultant. A research librarian conducted searches in Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. The methodology team supplemented searches of electronic databases with the studies included in the prior AUA review and by reviewing reference lists of relevant articles.Results:The Clinically Localized Prostate Cancer Panel created evidence- and consensus-based guideline statements to aid clinicians in the management of patients with clinically localized prostate cancer. Statements regarding management of patients using radiation therapy as well as important future directions of research are detailed herein.Conclusions:This guideline aims to inform clinicians treating patients with clinically localized prostate cancer. Continued research and publication of high-quality evidence from future trials will be essential to further improve care for these men.

AB - Purpose:The summary presented herein represents Part III of the three-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO Guideline, discussing principles of radiation and offering several future directions of further relevant study in patients diagnosed with clinically localized prostate cancer. Please refer to Parts I and II for discussion of risk assessment, staging, and risk-based management (Part I), and principles of active surveillance and surgery and follow-up (Part II).Materials and Methods:The systematic review utilized to inform this guideline was conducted by an independent methodological consultant. A research librarian conducted searches in Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. The methodology team supplemented searches of electronic databases with the studies included in the prior AUA review and by reviewing reference lists of relevant articles.Results:The Clinically Localized Prostate Cancer Panel created evidence- and consensus-based guideline statements to aid clinicians in the management of patients with clinically localized prostate cancer. Statements regarding management of patients using radiation therapy as well as important future directions of research are detailed herein.Conclusions:This guideline aims to inform clinicians treating patients with clinically localized prostate cancer. Continued research and publication of high-quality evidence from future trials will be essential to further improve care for these men.

KW - Active surveillance

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KW - Radiation therapy for prostate cancer

KW - Radical prostatectomy

KW - Shared decision making

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Clinically Localized Prostate Cancer: AUA/ASTRO Guideline. Part III: Principles of Radiation and Future Directions

Abstract

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