Abstract
A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance thermal imaging (MRTI) is used to measure 2D temperature rise distributions in four cross sections of large extremity soft tissue sarcomas during hyperthermia treatments. Novel hardware and software techniques aredescribed which improve the signal to noise ratio of MR images, minimize motion artifact from circulating coupling fluids, and provide accurate high resolution volumetric thermal dosimetry. For the first 10 extremity sarcoma patients, the mean difference between MRTI region of interest and adjacent interstitial point measurements during the period of steady state temperature was 0.85°C. With 1min temporal resolution of measurements in four image planes, this noninvasive MRTI approach has demonstrated its utility for accurate monitoring and realtime steering of heat into tumors at depth in the body.
Original language | English (US) |
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Article number | 71810I |
Journal | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
Volume | 7181 |
DOIs | |
State | Published - 2009 |
Externally published | Yes |
Event | Energy-based Treatment of Tissue and Assessment V - San Jose, CA, United States Duration: Jan 25 2009 → Jan 26 2009 |
Keywords
- Deep Hyperthermia
- Magnetic Resonance Temperature Imaging
- Non-Invasive Thermometry
- Radiofrequency Phased Array Heating
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Biomaterials
- Radiology Nuclear Medicine and imaging