Clinical utility of endorectal MRI-guided prostate biopsy: Preliminary experience

Adam J. Jung, Antonio C. Westphalen, John Kurhanewicz, Zhen J. Wang, Peter R. Carroll, Jeffry P. Simko, Fergus Coakley

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose To investigate the potential clinical utility of endorectal MRI-guided biopsy in patients with known or suspected prostate cancer. Materials and Methods We prospectively recruited 24 men with known or suspected prostate cancer in whom MRI-guided biopsy was clinically requested after multiparametric endorectal MRI showed one or more appropriate targets. One to six 18-gauge biopsy cores were obtained from each patient. Transrectal ultrasound guided biopsy results and post MRI-guided biopsy complications were also recorded. Results MRI-guided biopsy was positive in 5 of 7 patients with suspected prostate cancer (including 2 of 4 with prior negative ultrasound-guided biopsies), in 8 of 12 with known untreated prostate cancer (including 5 where MRI-guided biopsy demonstrated a higher Gleason score than ultrasound guided biopsy results), and in 3 of 5 with treated cancer. MRI-guided biopsies had a significantly higher maximum percentage of cancer in positive cores when compared with ultrasound guided biopsy (mean of 37 ± 8% versus 13 ± 4%; P = 0.01). No serious postbiopsy complications occurred. Conclusion Our preliminary experience suggests endorectal MRI-guided biopsy may safely contribute to the management of patients with known or suspected prostate cancer by making a new diagnosis of malignancy, upgrading previously diagnosed disease, or diagnosing local recurrence.

Original languageEnglish (US)
Pages (from-to)314-323
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume40
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Prostate
Biopsy
Prostatic Neoplasms
Neoplasms
Neoplasm Grading
Recurrence

Keywords

  • MR imaging
  • prostate biopsy
  • prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Jung, A. J., Westphalen, A. C., Kurhanewicz, J., Wang, Z. J., Carroll, P. R., Simko, J. P., & Coakley, F. (2014). Clinical utility of endorectal MRI-guided prostate biopsy: Preliminary experience. Journal of Magnetic Resonance Imaging, 40(2), 314-323. https://doi.org/10.1002/jmri.24383

Clinical utility of endorectal MRI-guided prostate biopsy : Preliminary experience. / Jung, Adam J.; Westphalen, Antonio C.; Kurhanewicz, John; Wang, Zhen J.; Carroll, Peter R.; Simko, Jeffry P.; Coakley, Fergus.

In: Journal of Magnetic Resonance Imaging, Vol. 40, No. 2, 2014, p. 314-323.

Research output: Contribution to journalArticle

Jung, AJ, Westphalen, AC, Kurhanewicz, J, Wang, ZJ, Carroll, PR, Simko, JP & Coakley, F 2014, 'Clinical utility of endorectal MRI-guided prostate biopsy: Preliminary experience', Journal of Magnetic Resonance Imaging, vol. 40, no. 2, pp. 314-323. https://doi.org/10.1002/jmri.24383
Jung, Adam J. ; Westphalen, Antonio C. ; Kurhanewicz, John ; Wang, Zhen J. ; Carroll, Peter R. ; Simko, Jeffry P. ; Coakley, Fergus. / Clinical utility of endorectal MRI-guided prostate biopsy : Preliminary experience. In: Journal of Magnetic Resonance Imaging. 2014 ; Vol. 40, No. 2. pp. 314-323.
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