Clinical trial enrollment of adolescents and young adults with sarcoma

Lara E. Davis, Katherine A. Janeway, Aaron R. Weiss, Yen Lin E. Chen, Thomas J. Scharschmidt, Mark Krailo, Julia L. Glade Bender, Lisa M. Kopp, Shreyaskumar R. Patel, Gary K. Schwartz, L. Elise Horvath, Douglas S. Hawkins, Meredith K. Chuk, Denise K. Reinke, Richard G. Gorlick, R. Lor Randall

Research output: Contribution to journalComment/debate

17 Scopus citations

Abstract

More than half of all sarcomas occur in adolescents and young adults (AYAs) aged 15 to 39 years. After the publication of the AYA series in the April 1, 2016 issue of Cancer, several leaders in the field of sarcoma across disciplines gathered to discuss the status of sarcoma clinical research in AYAs. They determined that a focused effort to include the underrepresented and understudied AYA population in current and future sarcoma clinical trials is overdue. Trial enrichment for AYA-aged sarcoma patients will produce more meaningful results that better represent the disease's biology, epidemiology, and treatment environment. To address the current deficit, this commentary outlines changes believed to be necessary to expediently achieve an increase in the enrollment of AYAs in sarcoma clinical trials. Cancer 2017;123:3434-40.

Original languageEnglish (US)
Pages (from-to)3434-3440
Number of pages7
JournalCancer
Volume123
Issue number18
DOIs
StatePublished - Sep 15 2017

Keywords

  • National Clinical Trials Network
  • adolescent
  • clinical trials
  • sarcoma
  • young adult

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Davis, L. E., Janeway, K. A., Weiss, A. R., Chen, Y. L. E., Scharschmidt, T. J., Krailo, M., Glade Bender, J. L., Kopp, L. M., Patel, S. R., Schwartz, G. K., Horvath, L. E., Hawkins, D. S., Chuk, M. K., Reinke, D. K., Gorlick, R. G., & Randall, R. L. (2017). Clinical trial enrollment of adolescents and young adults with sarcoma. Cancer, 123(18), 3434-3440. https://doi.org/10.1002/cncr.30757