CLINICAL STUDIES WITH RECOMBINANT-DNA-DERIVED METHIONYL HUMAN GROWTH HORMONE IN GROWTH HORMONE DEFICIENT CHILDREN

S. L. Kaplan, G. P. August, S. L. Blethen, D. R. Brown, R. L. Hintz, A. Johansen, L. P. Plotnick, L. E. Underwood, J. J. Bell, R. M. Blizzard, T. P. Foley, N. J. Hopwood, R. T. Kirkland, Ronald (Ron) Rosenfeld, J. J. Van Wyk

Research output: Contribution to journalArticle

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Abstract

Thirty-six children with growth hormone deficiency were treated for up to 48 months with methionyl human growth hormone (hGH) synthesised by DNA recombinant methods. The growth rate for these children increased from 3·2±1·1 cm/yr to 10 · 5±2·2 cm/yr (mean±SD). This was similar to the effect of pituitary hGH in ten GH deficient children, 3·8±1·0 to 10·1±1·1 cm/yr. Serum somatomedin C rose from 0·26±0·23 U/ml to 0·79±0·53 U/ml after 6 months of methionyl-hGH therapy, similar to the effect of pituitary hGH. The incidence of antibody formation to methionyl-hGH was higher than that observed with pituitary hGH (Kabi) but poor growth was observed only in the one patient on methionyl-hGH who acquired high-titre high-binding-capacity antibodies to hGH. No consistent changes in levels of antibodies to Escherichia coli proteins were detected. No other allergic manifestations or systemic side-effects were demonstrable.

Original languageEnglish (US)
Pages (from-to)697-700
Number of pages4
JournalThe Lancet
Volume327
Issue number8483
DOIs
StatePublished - Mar 29 1986
Externally publishedYes

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Recombinant DNA
Human Growth Hormone
Growth Hormone
Antibodies
Escherichia coli Proteins
Growth
Insulin-Like Growth Factor I
Antibody Formation
somatrem
Clinical Studies
Incidence
Serum
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kaplan, S. L., August, G. P., Blethen, S. L., Brown, D. R., Hintz, R. L., Johansen, A., ... Van Wyk, J. J. (1986). CLINICAL STUDIES WITH RECOMBINANT-DNA-DERIVED METHIONYL HUMAN GROWTH HORMONE IN GROWTH HORMONE DEFICIENT CHILDREN. The Lancet, 327(8483), 697-700. https://doi.org/10.1016/S0140-6736(86)91098-6

CLINICAL STUDIES WITH RECOMBINANT-DNA-DERIVED METHIONYL HUMAN GROWTH HORMONE IN GROWTH HORMONE DEFICIENT CHILDREN. / Kaplan, S. L.; August, G. P.; Blethen, S. L.; Brown, D. R.; Hintz, R. L.; Johansen, A.; Plotnick, L. P.; Underwood, L. E.; Bell, J. J.; Blizzard, R. M.; Foley, T. P.; Hopwood, N. J.; Kirkland, R. T.; Rosenfeld, Ronald (Ron); Van Wyk, J. J.

In: The Lancet, Vol. 327, No. 8483, 29.03.1986, p. 697-700.

Research output: Contribution to journalArticle

Kaplan, SL, August, GP, Blethen, SL, Brown, DR, Hintz, RL, Johansen, A, Plotnick, LP, Underwood, LE, Bell, JJ, Blizzard, RM, Foley, TP, Hopwood, NJ, Kirkland, RT, Rosenfeld, RR & Van Wyk, JJ 1986, 'CLINICAL STUDIES WITH RECOMBINANT-DNA-DERIVED METHIONYL HUMAN GROWTH HORMONE IN GROWTH HORMONE DEFICIENT CHILDREN', The Lancet, vol. 327, no. 8483, pp. 697-700. https://doi.org/10.1016/S0140-6736(86)91098-6
Kaplan, S. L. ; August, G. P. ; Blethen, S. L. ; Brown, D. R. ; Hintz, R. L. ; Johansen, A. ; Plotnick, L. P. ; Underwood, L. E. ; Bell, J. J. ; Blizzard, R. M. ; Foley, T. P. ; Hopwood, N. J. ; Kirkland, R. T. ; Rosenfeld, Ronald (Ron) ; Van Wyk, J. J. / CLINICAL STUDIES WITH RECOMBINANT-DNA-DERIVED METHIONYL HUMAN GROWTH HORMONE IN GROWTH HORMONE DEFICIENT CHILDREN. In: The Lancet. 1986 ; Vol. 327, No. 8483. pp. 697-700.
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