Clinical studies of intrathecal autologous lymphocyte infusions in patients with malignant glioma: A toxicity study

Edward A. Neuwelt, Kemp Clark, Joel B. Kirkpatrick, Howard Toben

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The feasibility and toxicity of intrathecal lymphoid cell infusions in patients with glioma were examined in this study. Blood rich in lymphoid cells was obtained using the Haemonetics Model 30 cell separator; the lymphoid cells extracted were further purified on Ficoll‐Hypaque gradients. Four patients received a total of eighteen autologous lymphoid cell infusions, with between 1 × 106 and 5 × 109 lymphoid cells being infused on each occasion. No toxicity was observed, but the CSF glucose declined in 2 patients. In 1 patient examined at autopsy the lymphoid cells appeared to have gained access to the tumor bed as well as to the rest of the subarachnoid space.

Original languageEnglish (US)
Pages (from-to)307-312
Number of pages6
JournalAnnals of Neurology
Volume4
Issue number4
DOIs
StatePublished - Oct 1978

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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