Clinical review of histamine2 receptor antagonists

R. J. Lipsy, B. Fennerty, T. C. Fagan

Research output: Contribution to journalReview article

78 Scopus citations

Abstract

Histamine2 receptor antagonists are beneficial in treating gastric and duodenal ulcers, gastroesophageal reflux, and hypersecretory states. Histamine2 receptor antagonists are helpful for the prevention of stress ulceration and recurrence of gastric and duodenal ulcer. Four histamine2 blockers are approved for clinical use: cimetidine, famotidine, ranitidine, and nizatidine. This review compares these agents in three areas: efficacy, adverse drug reactions, and drug interactions. Although limited published data exist for famotidine and nizatidine, both are as effective as the better-studied ranitidine and cimetidine when administered appropriately. Subtle differences exist among the four agents in the areas of drug interactions and adverse effects. Individual practitioners may decide if these differences are important enough to affect drug choice.

Original languageEnglish (US)
Pages (from-to)745-751
Number of pages7
JournalArchives of internal medicine
Volume150
Issue number4
DOIs
StatePublished - May 2 1990

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ASJC Scopus subject areas

  • Internal Medicine

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