Clinical review of histamine2 receptor antagonists

Robert J. Lipsy, M (Brian) Fennerty, Timothy C. Fagan

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Histamine2 receptor antagonists are beneficial in treating gastric and duodenal ulcers, gastroesophageal reflux, and hypersecretory states. Histamine2 receptor antagonists are helpful for the prevention of stress ulceration and recurrence of gastric and duodenal ulcer. Four histamine2 blockers are approved for clinical use: cimetidine, famotidine, ranitidine, and nizatidine. This review compares these agents in three areas: efficacy, adverse drug reactions, and drug interactions. Although limited published data exist for famotidine and nizatidine, both are as effective as the better-studied ranitidine and cimetidine when administered appropriately. Subtle differences exist among the four agents in the areas of drug interactions and adverse effects. Individual practitioners may decide if these differences are important enough to affect drug choice.

Original languageEnglish (US)
Pages (from-to)745-751
Number of pages7
JournalArchives of Internal Medicine
Volume150
Issue number4
StatePublished - Apr 1990
Externally publishedYes

Fingerprint

Nizatidine
Famotidine
Ranitidine
Cimetidine
Stomach Ulcer
Duodenal Ulcer
Drug Interactions
Gastroesophageal Reflux
Drug-Related Side Effects and Adverse Reactions
Recurrence
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Clinical review of histamine2 receptor antagonists. / Lipsy, Robert J.; Fennerty, M (Brian); Fagan, Timothy C.

In: Archives of Internal Medicine, Vol. 150, No. 4, 04.1990, p. 745-751.

Research output: Contribution to journalArticle

Lipsy, RJ, Fennerty, MB & Fagan, TC 1990, 'Clinical review of histamine2 receptor antagonists', Archives of Internal Medicine, vol. 150, no. 4, pp. 745-751.
Lipsy, Robert J. ; Fennerty, M (Brian) ; Fagan, Timothy C. / Clinical review of histamine2 receptor antagonists. In: Archives of Internal Medicine. 1990 ; Vol. 150, No. 4. pp. 745-751.
@article{e9eff942f76a4f74acb8479279d174e6,
title = "Clinical review of histamine2 receptor antagonists",
abstract = "Histamine2 receptor antagonists are beneficial in treating gastric and duodenal ulcers, gastroesophageal reflux, and hypersecretory states. Histamine2 receptor antagonists are helpful for the prevention of stress ulceration and recurrence of gastric and duodenal ulcer. Four histamine2 blockers are approved for clinical use: cimetidine, famotidine, ranitidine, and nizatidine. This review compares these agents in three areas: efficacy, adverse drug reactions, and drug interactions. Although limited published data exist for famotidine and nizatidine, both are as effective as the better-studied ranitidine and cimetidine when administered appropriately. Subtle differences exist among the four agents in the areas of drug interactions and adverse effects. Individual practitioners may decide if these differences are important enough to affect drug choice.",
author = "Lipsy, {Robert J.} and Fennerty, {M (Brian)} and Fagan, {Timothy C.}",
year = "1990",
month = "4",
language = "English (US)",
volume = "150",
pages = "745--751",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "4",

}

TY - JOUR

T1 - Clinical review of histamine2 receptor antagonists

AU - Lipsy, Robert J.

AU - Fennerty, M (Brian)

AU - Fagan, Timothy C.

PY - 1990/4

Y1 - 1990/4

N2 - Histamine2 receptor antagonists are beneficial in treating gastric and duodenal ulcers, gastroesophageal reflux, and hypersecretory states. Histamine2 receptor antagonists are helpful for the prevention of stress ulceration and recurrence of gastric and duodenal ulcer. Four histamine2 blockers are approved for clinical use: cimetidine, famotidine, ranitidine, and nizatidine. This review compares these agents in three areas: efficacy, adverse drug reactions, and drug interactions. Although limited published data exist for famotidine and nizatidine, both are as effective as the better-studied ranitidine and cimetidine when administered appropriately. Subtle differences exist among the four agents in the areas of drug interactions and adverse effects. Individual practitioners may decide if these differences are important enough to affect drug choice.

AB - Histamine2 receptor antagonists are beneficial in treating gastric and duodenal ulcers, gastroesophageal reflux, and hypersecretory states. Histamine2 receptor antagonists are helpful for the prevention of stress ulceration and recurrence of gastric and duodenal ulcer. Four histamine2 blockers are approved for clinical use: cimetidine, famotidine, ranitidine, and nizatidine. This review compares these agents in three areas: efficacy, adverse drug reactions, and drug interactions. Although limited published data exist for famotidine and nizatidine, both are as effective as the better-studied ranitidine and cimetidine when administered appropriately. Subtle differences exist among the four agents in the areas of drug interactions and adverse effects. Individual practitioners may decide if these differences are important enough to affect drug choice.

UR - http://www.scopus.com/inward/record.url?scp=0025194063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025194063&partnerID=8YFLogxK

M3 - Article

C2 - 1970232

AN - SCOPUS:0025194063

VL - 150

SP - 745

EP - 751

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 4

ER -