Abstract
Sarcoids are a locally invasive cutaneous fibroblastic neoplasia and are the most common skin tumor of equids. Myriad treatments are described in the literature including surgery, topical blistering agents, cryosurgery, immunotherapy, and intralesional chemotherapy. Recurrence or progression of the disease after treatment is common. Two years ago the authors began clinical trials investigating the feasibility of photodynamic therapy for the treatment of sarcoid tumors. The tumor or surgical margins were treated using topical or intra-lesional delta-aminolevulinic acid (ALA) as a photosensitizing agent. The ALA was left in situ for a period of time allowing buildup of protoporphyrin IX (the photosensitizer) prior to irradiation with a 635-nm diode laser. We have initial results in 10 patients with 18 lesions and have seen decrease in tumor size or complete remission in 13 of 18 lesions. Recurrence or progression has been noted in 7 lesions. Results of these trials and follow-up information on clinical patients will be presented for review.
| Original language | English (US) |
|---|---|
| Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Editors | K.E. Bartels, L.S. Bass, W.T.W. Riese, K.W. Gregory, H. Hirschberg, A. Katzir, N. Kollias, S.J. Madsen, R.S. Malek |
| Pages | 313-325 |
| Number of pages | 13 |
| Volume | 5 |
| Edition | 1 |
| DOIs | |
| State | Published - 2004 |
| Event | Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV - San Jose, CA, United States Duration: Jan 24 2004 → Jan 27 2004 |
Other
| Other | Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV |
|---|---|
| Country | United States |
| City | San Jose, CA |
| Period | 1/24/04 → 1/27/04 |
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Keywords
- Amino-levulinic acid
- Equid
- Laser
- Photodynamic therapy
- Sarcoids
- Tumor
ASJC Scopus subject areas
- Engineering(all)
Cite this
Clinical results of photodynamic therapy for the treatment of sarcoid tumors in equids. / Gustafson, Scott B.; Engelking, Kirstin; Jacques, Steven; Bildfell, Robert.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / K.E. Bartels; L.S. Bass; W.T.W. Riese; K.W. Gregory; H. Hirschberg; A. Katzir; N. Kollias; S.J. Madsen; R.S. Malek. Vol. 5 1. ed. 2004. p. 313-325 62.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Clinical results of photodynamic therapy for the treatment of sarcoid tumors in equids
AU - Gustafson, Scott B.
AU - Engelking, Kirstin
AU - Jacques, Steven
AU - Bildfell, Robert
PY - 2004
Y1 - 2004
N2 - Sarcoids are a locally invasive cutaneous fibroblastic neoplasia and are the most common skin tumor of equids. Myriad treatments are described in the literature including surgery, topical blistering agents, cryosurgery, immunotherapy, and intralesional chemotherapy. Recurrence or progression of the disease after treatment is common. Two years ago the authors began clinical trials investigating the feasibility of photodynamic therapy for the treatment of sarcoid tumors. The tumor or surgical margins were treated using topical or intra-lesional delta-aminolevulinic acid (ALA) as a photosensitizing agent. The ALA was left in situ for a period of time allowing buildup of protoporphyrin IX (the photosensitizer) prior to irradiation with a 635-nm diode laser. We have initial results in 10 patients with 18 lesions and have seen decrease in tumor size or complete remission in 13 of 18 lesions. Recurrence or progression has been noted in 7 lesions. Results of these trials and follow-up information on clinical patients will be presented for review.
AB - Sarcoids are a locally invasive cutaneous fibroblastic neoplasia and are the most common skin tumor of equids. Myriad treatments are described in the literature including surgery, topical blistering agents, cryosurgery, immunotherapy, and intralesional chemotherapy. Recurrence or progression of the disease after treatment is common. Two years ago the authors began clinical trials investigating the feasibility of photodynamic therapy for the treatment of sarcoid tumors. The tumor or surgical margins were treated using topical or intra-lesional delta-aminolevulinic acid (ALA) as a photosensitizing agent. The ALA was left in situ for a period of time allowing buildup of protoporphyrin IX (the photosensitizer) prior to irradiation with a 635-nm diode laser. We have initial results in 10 patients with 18 lesions and have seen decrease in tumor size or complete remission in 13 of 18 lesions. Recurrence or progression has been noted in 7 lesions. Results of these trials and follow-up information on clinical patients will be presented for review.
KW - Amino-levulinic acid
KW - Equid
KW - Laser
KW - Photodynamic therapy
KW - Sarcoids
KW - Tumor
UR - http://www.scopus.com/inward/record.url?scp=12144267409&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12144267409&partnerID=8YFLogxK
U2 - 10.1117/12.528079
DO - 10.1117/12.528079
M3 - Conference contribution
VL - 5
SP - 313
EP - 325
BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
A2 - Bartels, K.E.
A2 - Bass, L.S.
A2 - Riese, W.T.W.
A2 - Gregory, K.W.
A2 - Hirschberg, H.
A2 - Katzir, A.
A2 - Kollias, N.
A2 - Madsen, S.J.
A2 - Malek, R.S.
ER -