Clinical Presentation and Anatomical Location of Orbital Plasmacytomas

Bradley A. Thuro, Oded Sagiv, Roman Shinder, Matthew M. Debnam, Omar Ozgur, John Ng, Daniel Rootman, Sheeba K. Thomas, Bita Esmaeli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

PURPOSE:: To evaluate the clinical and anatomical location of orbital plasmacytomas and assess local control following therapy. METHODS:: The American Society of Ophthalmic Plastic and Reconstructive Surgery Oncology Database was queried to identify patients diagnosed with orbital plasmacytoma. These patients’ records were reviewed for demographic characteristics, clinical and radiologic findings, treatments, and outcomes. RESULTS:: Thirty patients from 4 institutions (24 from MD Anderson Cancer Center, 3 from SUNY Downstate Medical Center, 2 from University of California, Los Angeles, and 1 from Oregon Health and Science University) were identified. Eighteen patients (60%) were diagnosed with multiple myeloma (MM) before and 11 (37%) were diagnosed with MM immediately after orbital plasmacytoma. Based on imaging, 4 distinct anatomical patterns were identified: 1) bony plasmacytoma affecting the superotemporal orbit, epidural space, and temporal fossa (15 patients; 50%); 2) discrete orbital plasmacytoma (7 patients; 23%); 3) infiltrative plasmacytoma either originating from a sinus (4 patients; 13%); or 4) originating from the orbital floor and infiltrating facial soft tissue (4 patients; 13%). Of the 29 patients with available treatment data, 2 had radiation only, 3 had chemotherapy only, 6 had chemoradiation, and 18 had stem cell transplant following chemoradiation (n = 17) or only chemotherapy (n = 1). Following treatment, 10 patients achieved complete and 11 achieved partial responses. CONCLUSION:: Orbital plasmacytomas were found exclusively in patients with MM diagnosed before or immediately after orbital plasmacytoma. Plasmacytomas can have 4 distinct anatomical patterns of origin. Following treatment, all patients had good to excellent local control of their orbital lesions.

Original languageEnglish (US)
JournalOphthalmic Plastic and Reconstructive Surgery
DOIs
StateAccepted/In press - Jun 2 2017

Fingerprint

Plasmacytoma
Multiple Myeloma
Reconstructive Surgical Procedures
Epidural Space
Drug Therapy
Los Angeles
Orbit
Plastic Surgery
Therapeutics
Stem Cells
Demography

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Clinical Presentation and Anatomical Location of Orbital Plasmacytomas. / Thuro, Bradley A.; Sagiv, Oded; Shinder, Roman; Debnam, Matthew M.; Ozgur, Omar; Ng, John; Rootman, Daniel; Thomas, Sheeba K.; Esmaeli, Bita.

In: Ophthalmic Plastic and Reconstructive Surgery, 02.06.2017.

Research output: Contribution to journalArticle

Thuro, Bradley A. ; Sagiv, Oded ; Shinder, Roman ; Debnam, Matthew M. ; Ozgur, Omar ; Ng, John ; Rootman, Daniel ; Thomas, Sheeba K. ; Esmaeli, Bita. / Clinical Presentation and Anatomical Location of Orbital Plasmacytomas. In: Ophthalmic Plastic and Reconstructive Surgery. 2017.
@article{02eb5a5405d14e74b4cd17ff1711bd13,
title = "Clinical Presentation and Anatomical Location of Orbital Plasmacytomas",
abstract = "PURPOSE:: To evaluate the clinical and anatomical location of orbital plasmacytomas and assess local control following therapy. METHODS:: The American Society of Ophthalmic Plastic and Reconstructive Surgery Oncology Database was queried to identify patients diagnosed with orbital plasmacytoma. These patients’ records were reviewed for demographic characteristics, clinical and radiologic findings, treatments, and outcomes. RESULTS:: Thirty patients from 4 institutions (24 from MD Anderson Cancer Center, 3 from SUNY Downstate Medical Center, 2 from University of California, Los Angeles, and 1 from Oregon Health and Science University) were identified. Eighteen patients (60{\%}) were diagnosed with multiple myeloma (MM) before and 11 (37{\%}) were diagnosed with MM immediately after orbital plasmacytoma. Based on imaging, 4 distinct anatomical patterns were identified: 1) bony plasmacytoma affecting the superotemporal orbit, epidural space, and temporal fossa (15 patients; 50{\%}); 2) discrete orbital plasmacytoma (7 patients; 23{\%}); 3) infiltrative plasmacytoma either originating from a sinus (4 patients; 13{\%}); or 4) originating from the orbital floor and infiltrating facial soft tissue (4 patients; 13{\%}). Of the 29 patients with available treatment data, 2 had radiation only, 3 had chemotherapy only, 6 had chemoradiation, and 18 had stem cell transplant following chemoradiation (n = 17) or only chemotherapy (n = 1). Following treatment, 10 patients achieved complete and 11 achieved partial responses. CONCLUSION:: Orbital plasmacytomas were found exclusively in patients with MM diagnosed before or immediately after orbital plasmacytoma. Plasmacytomas can have 4 distinct anatomical patterns of origin. Following treatment, all patients had good to excellent local control of their orbital lesions.",
author = "Thuro, {Bradley A.} and Oded Sagiv and Roman Shinder and Debnam, {Matthew M.} and Omar Ozgur and John Ng and Daniel Rootman and Thomas, {Sheeba K.} and Bita Esmaeli",
year = "2017",
month = "6",
day = "2",
doi = "10.1097/IOP.0000000000000939",
language = "English (US)",
journal = "Ophthalmic Plastic and Reconstructive Surgery",
issn = "0740-9303",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Clinical Presentation and Anatomical Location of Orbital Plasmacytomas

AU - Thuro, Bradley A.

AU - Sagiv, Oded

AU - Shinder, Roman

AU - Debnam, Matthew M.

AU - Ozgur, Omar

AU - Ng, John

AU - Rootman, Daniel

AU - Thomas, Sheeba K.

AU - Esmaeli, Bita

PY - 2017/6/2

Y1 - 2017/6/2

N2 - PURPOSE:: To evaluate the clinical and anatomical location of orbital plasmacytomas and assess local control following therapy. METHODS:: The American Society of Ophthalmic Plastic and Reconstructive Surgery Oncology Database was queried to identify patients diagnosed with orbital plasmacytoma. These patients’ records were reviewed for demographic characteristics, clinical and radiologic findings, treatments, and outcomes. RESULTS:: Thirty patients from 4 institutions (24 from MD Anderson Cancer Center, 3 from SUNY Downstate Medical Center, 2 from University of California, Los Angeles, and 1 from Oregon Health and Science University) were identified. Eighteen patients (60%) were diagnosed with multiple myeloma (MM) before and 11 (37%) were diagnosed with MM immediately after orbital plasmacytoma. Based on imaging, 4 distinct anatomical patterns were identified: 1) bony plasmacytoma affecting the superotemporal orbit, epidural space, and temporal fossa (15 patients; 50%); 2) discrete orbital plasmacytoma (7 patients; 23%); 3) infiltrative plasmacytoma either originating from a sinus (4 patients; 13%); or 4) originating from the orbital floor and infiltrating facial soft tissue (4 patients; 13%). Of the 29 patients with available treatment data, 2 had radiation only, 3 had chemotherapy only, 6 had chemoradiation, and 18 had stem cell transplant following chemoradiation (n = 17) or only chemotherapy (n = 1). Following treatment, 10 patients achieved complete and 11 achieved partial responses. CONCLUSION:: Orbital plasmacytomas were found exclusively in patients with MM diagnosed before or immediately after orbital plasmacytoma. Plasmacytomas can have 4 distinct anatomical patterns of origin. Following treatment, all patients had good to excellent local control of their orbital lesions.

AB - PURPOSE:: To evaluate the clinical and anatomical location of orbital plasmacytomas and assess local control following therapy. METHODS:: The American Society of Ophthalmic Plastic and Reconstructive Surgery Oncology Database was queried to identify patients diagnosed with orbital plasmacytoma. These patients’ records were reviewed for demographic characteristics, clinical and radiologic findings, treatments, and outcomes. RESULTS:: Thirty patients from 4 institutions (24 from MD Anderson Cancer Center, 3 from SUNY Downstate Medical Center, 2 from University of California, Los Angeles, and 1 from Oregon Health and Science University) were identified. Eighteen patients (60%) were diagnosed with multiple myeloma (MM) before and 11 (37%) were diagnosed with MM immediately after orbital plasmacytoma. Based on imaging, 4 distinct anatomical patterns were identified: 1) bony plasmacytoma affecting the superotemporal orbit, epidural space, and temporal fossa (15 patients; 50%); 2) discrete orbital plasmacytoma (7 patients; 23%); 3) infiltrative plasmacytoma either originating from a sinus (4 patients; 13%); or 4) originating from the orbital floor and infiltrating facial soft tissue (4 patients; 13%). Of the 29 patients with available treatment data, 2 had radiation only, 3 had chemotherapy only, 6 had chemoradiation, and 18 had stem cell transplant following chemoradiation (n = 17) or only chemotherapy (n = 1). Following treatment, 10 patients achieved complete and 11 achieved partial responses. CONCLUSION:: Orbital plasmacytomas were found exclusively in patients with MM diagnosed before or immediately after orbital plasmacytoma. Plasmacytomas can have 4 distinct anatomical patterns of origin. Following treatment, all patients had good to excellent local control of their orbital lesions.

UR - http://www.scopus.com/inward/record.url?scp=85020198310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020198310&partnerID=8YFLogxK

U2 - 10.1097/IOP.0000000000000939

DO - 10.1097/IOP.0000000000000939

M3 - Article

C2 - 28582371

AN - SCOPUS:85020198310

JO - Ophthalmic Plastic and Reconstructive Surgery

JF - Ophthalmic Plastic and Reconstructive Surgery

SN - 0740-9303

ER -