Clinical laboratory reports in molecular pathology

Margaret L. Gulley, Rita Braziel, Kevin C. Halling, Eric D. Hsi, Jeffrey A. Kant, Marina N. Nikiforova, Jan A. Nowak, Shuji Ogino, Andre Oliveira, Herbert F. Polesky, Lawrence Silverman, Raymond R. Tubbs, Vivianna M. Van Deerlin, Gail H. Vance, James Versalovic

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Context. - Molecular pathology is a rapidly growing area of laboratory medicine in which DNA and RNA are analyzed. The recent introduction of array technology has added another layer of complexity involving massive parallel analysis of multiple genes, transcripts, or proteins. Objective. - As molecular technologies are increasingly implemented in clinical settings, it is important to bring uniformity to the way that test results are reported. Data Sources. - The College of American Pathologists Molecular Pathology Resource Committee members summarize elements that are already common to virtually all molecular pathology reports, as set forth in the College of American Pathologists checklists used in the laboratory accreditation process. Consensus recommendations are proposed to improve report format and content, and areas of controversy are discussed. Resources are cited that promote use of proper gene nomenclature and that describe methods for reporting mutations, translocations, microsatellite instability, and other genetic alterations related to inherited disease, cancer, identity testing, microbiology, and pharmacogenetics. Conclusions. - These resources and recommendations provide a framework for composing patient reports to convey molecular test results and their clinical significance to members of the health care team.

Original languageEnglish (US)
Pages (from-to)852-863
Number of pages12
JournalArchives of Pathology and Laboratory Medicine
Volume131
Issue number6
StatePublished - Jun 2007

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Molecular Pathology
Committee Membership
Technology
Microsatellite Instability
Patient Care Team
Accreditation
Information Storage and Retrieval
Microbiology
Checklist
Terminology
Genes
Medicine
RNA
Mutation
DNA
Neoplasms
Proteins
Pathologists

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Gulley, M. L., Braziel, R., Halling, K. C., Hsi, E. D., Kant, J. A., Nikiforova, M. N., ... Versalovic, J. (2007). Clinical laboratory reports in molecular pathology. Archives of Pathology and Laboratory Medicine, 131(6), 852-863.

Clinical laboratory reports in molecular pathology. / Gulley, Margaret L.; Braziel, Rita; Halling, Kevin C.; Hsi, Eric D.; Kant, Jeffrey A.; Nikiforova, Marina N.; Nowak, Jan A.; Ogino, Shuji; Oliveira, Andre; Polesky, Herbert F.; Silverman, Lawrence; Tubbs, Raymond R.; Van Deerlin, Vivianna M.; Vance, Gail H.; Versalovic, James.

In: Archives of Pathology and Laboratory Medicine, Vol. 131, No. 6, 06.2007, p. 852-863.

Research output: Contribution to journalArticle

Gulley, ML, Braziel, R, Halling, KC, Hsi, ED, Kant, JA, Nikiforova, MN, Nowak, JA, Ogino, S, Oliveira, A, Polesky, HF, Silverman, L, Tubbs, RR, Van Deerlin, VM, Vance, GH & Versalovic, J 2007, 'Clinical laboratory reports in molecular pathology', Archives of Pathology and Laboratory Medicine, vol. 131, no. 6, pp. 852-863.
Gulley ML, Braziel R, Halling KC, Hsi ED, Kant JA, Nikiforova MN et al. Clinical laboratory reports in molecular pathology. Archives of Pathology and Laboratory Medicine. 2007 Jun;131(6):852-863.
Gulley, Margaret L. ; Braziel, Rita ; Halling, Kevin C. ; Hsi, Eric D. ; Kant, Jeffrey A. ; Nikiforova, Marina N. ; Nowak, Jan A. ; Ogino, Shuji ; Oliveira, Andre ; Polesky, Herbert F. ; Silverman, Lawrence ; Tubbs, Raymond R. ; Van Deerlin, Vivianna M. ; Vance, Gail H. ; Versalovic, James. / Clinical laboratory reports in molecular pathology. In: Archives of Pathology and Laboratory Medicine. 2007 ; Vol. 131, No. 6. pp. 852-863.
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