Clinical, laboratory, and environmental features of infant botulism in Southeastern Pennsylvania

S. S. Long, J. L. Gajewski, L. W. Brown, P. H. Gilligan

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Forty-four cases of botulism occurred in infants in Southeastern Pennsylvania between 1976 and 1983. Forty-three were caused by Clostridium botulinum type B. Progressive weakness necessitated ventilatory support in 39 infants. Complications during hospitalization included otitis media in 13 patients and aspiration pneumonia in 11. Eight infants developed the syndrome of inappropriate secretion of antidiuretic hormone and 2 developed adult respiratory distress syndrome. One infant died of progressive bradycardia despite adequate control of ventilation. Manifestations of autonomic nervous system dysfunction recognized on admission to the hospital were constipation, distention of the urinary bladder, and decreased salivation and tearing. During hospitalization, some infants had unexpected fluctuations of skin color, blood pressure, and heart rate. Infants' strength improved despite persistent intestinal elaboration of toxin. C. botulinum was isolated from 7 of 9 home or work environments samples. All 44 infants were white and were receiving breast milk at the time of onset of symptoms. The majority had first feedings of nonhuman food substances within 4 weeks prior to onset of symptoms. Delineation of fecal flora in 7 infants revealed predominance of enterobacteriaceae. Perturbations of intestinal flora during infancy, especially at weaning, may cause transient permissiveness to colonization by C. botulinum.

Original languageEnglish (US)
Pages (from-to)935-941
Number of pages7
JournalPediatrics
Volume75
Issue number5
StatePublished - 1985
Externally publishedYes

Fingerprint

Botulism
Clostridium botulinum
Clostridium botulinum type B
Hospitalization
Permissiveness
Inappropriate ADH Syndrome
Skin Pigmentation
Salivation
Aspiration Pneumonia
Autonomic Nervous System
Adult Respiratory Distress Syndrome
Otitis Media
Human Milk
Enterobacteriaceae
Constipation
Bradycardia
Weaning
Ventilation
Urinary Bladder
Heart Rate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Long, S. S., Gajewski, J. L., Brown, L. W., & Gilligan, P. H. (1985). Clinical, laboratory, and environmental features of infant botulism in Southeastern Pennsylvania. Pediatrics, 75(5), 935-941.

Clinical, laboratory, and environmental features of infant botulism in Southeastern Pennsylvania. / Long, S. S.; Gajewski, J. L.; Brown, L. W.; Gilligan, P. H.

In: Pediatrics, Vol. 75, No. 5, 1985, p. 935-941.

Research output: Contribution to journalArticle

Long, SS, Gajewski, JL, Brown, LW & Gilligan, PH 1985, 'Clinical, laboratory, and environmental features of infant botulism in Southeastern Pennsylvania', Pediatrics, vol. 75, no. 5, pp. 935-941.
Long, S. S. ; Gajewski, J. L. ; Brown, L. W. ; Gilligan, P. H. / Clinical, laboratory, and environmental features of infant botulism in Southeastern Pennsylvania. In: Pediatrics. 1985 ; Vol. 75, No. 5. pp. 935-941.
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