Abstract
The clinical impact of catheter diameter variability on performance of neonatal continuous arteriovenous hemofiltration (CAVH) systems was shown by demonstration of the effect of catheter inner diameter on catheter and CAVH system blood flow. Diameter of 3.5 Fr and 5 Fr catheters was determined by experimental measurement of catheter flow-pressure drop relationship with known equations for fluid flow. Physical measurements verified the accuracy of the calculated diameters. These diameters were then used in a mathematical simulation to describe blood flow through an entire neonatal CAVH system and predict clinical performance. Catheters of 5 Fr caliber had a 39% variation in diameter among manufacturers, resulting in a 370% variation in blood flows; 3.5 Fr catheters had a 29% variation in internal diameter with a corresponding blood flow variation of 290%. Computer simulation of a neonatal CAVH system revealed a maximum blood flow of 0.8-3.0 ml/min with available 5 Fr catheters. This wide variation is probably responsible for the lack of consistant results in neonatal CAVH systems to date.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 108-111 |
| Number of pages | 4 |
| Journal | ASAIO Transactions |
| Volume | 34 |
| Issue number | 2 |
| State | Published - Apr 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biophysics
Cite this
Clinical implications of catheter variability on neonatal continuous arteriovenous hemofiltration. / Jenkins, Randall; Kuhn, R. J.; Funk, J. E.
In: ASAIO Transactions, Vol. 34, No. 2, 04.1988, p. 108-111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical implications of catheter variability on neonatal continuous arteriovenous hemofiltration
AU - Jenkins, Randall
AU - Kuhn, R. J.
AU - Funk, J. E.
PY - 1988/4
Y1 - 1988/4
N2 - The clinical impact of catheter diameter variability on performance of neonatal continuous arteriovenous hemofiltration (CAVH) systems was shown by demonstration of the effect of catheter inner diameter on catheter and CAVH system blood flow. Diameter of 3.5 Fr and 5 Fr catheters was determined by experimental measurement of catheter flow-pressure drop relationship with known equations for fluid flow. Physical measurements verified the accuracy of the calculated diameters. These diameters were then used in a mathematical simulation to describe blood flow through an entire neonatal CAVH system and predict clinical performance. Catheters of 5 Fr caliber had a 39% variation in diameter among manufacturers, resulting in a 370% variation in blood flows; 3.5 Fr catheters had a 29% variation in internal diameter with a corresponding blood flow variation of 290%. Computer simulation of a neonatal CAVH system revealed a maximum blood flow of 0.8-3.0 ml/min with available 5 Fr catheters. This wide variation is probably responsible for the lack of consistant results in neonatal CAVH systems to date.
AB - The clinical impact of catheter diameter variability on performance of neonatal continuous arteriovenous hemofiltration (CAVH) systems was shown by demonstration of the effect of catheter inner diameter on catheter and CAVH system blood flow. Diameter of 3.5 Fr and 5 Fr catheters was determined by experimental measurement of catheter flow-pressure drop relationship with known equations for fluid flow. Physical measurements verified the accuracy of the calculated diameters. These diameters were then used in a mathematical simulation to describe blood flow through an entire neonatal CAVH system and predict clinical performance. Catheters of 5 Fr caliber had a 39% variation in diameter among manufacturers, resulting in a 370% variation in blood flows; 3.5 Fr catheters had a 29% variation in internal diameter with a corresponding blood flow variation of 290%. Computer simulation of a neonatal CAVH system revealed a maximum blood flow of 0.8-3.0 ml/min with available 5 Fr catheters. This wide variation is probably responsible for the lack of consistant results in neonatal CAVH systems to date.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024000393&partnerID=8YFLogxK
M3 - Article
C2 - 3370172
AN - SCOPUS:0024000393
VL - 34
SP - 108
EP - 111
JO - ASAIO Journal
JF - ASAIO Journal
SN - 1058-2916
IS - 2
ER -