Clinical Epidemiology, Evaluation, and Management of Dementia in Parkinson Disease

Delaram Safarpour, Allison W. Willis

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

The prevalence of neurodegenerative diseases such as Parkinson disease (PD) will increase substantially, due to the aging of the population and improved treatments leading to better disease-related outcomes. Dementia is the most common nonmotor symptom in PD, and most patients with PD will have cognitive dysfunction and cognitive decline in the course of their disease. The development of cognitive dysfunction in PD greatly limits the ability to participate in activities of daily living and can be a tipping point for nursing home placement or major caregiver stress. Understanding the different causes of dementia and how to reduce the incidence and impact of secondary cognitive dysfunction in PD are necessary skills for primary care physicians and neurologists. In this review, we discuss the clinical epidemiology of dementia in PD with an emphasis on preventable cognitive dysfunction, present tools for outpatient evaluation of cognitive dysfunction, and describe current pharmacological treatments for dementia in PD.

Original languageEnglish (US)
Pages (from-to)585-594
Number of pages10
JournalAmerican Journal of Alzheimer's Disease and other Dementias
Volume31
Issue number7
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • dementia
  • epidemiology
  • mild cognitive impairment
  • Parkinson disease
  • Parkinson disease with dementia

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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