Clinical effects of a combination treatment with fosfomycin and clavulanic acid/ticarcillin for infections in patients complicated with hematological disorders

Kouichi Hirakawa, Shouichirou Tsuda, Shinichi Misawa, Yutaka Ueda, Hiroto Kaneko, Makoto Nakao, Yuko Ariyama, Hiroyuki Nakai, Taku Seriu, Teruyuki Takashima, Shinji Tanaka, Hikari Nishigaki, Shouhei Yokota, Shigeo Horiike, Masashi Taniwaki, Kei Kashima

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We evaluated clinical effects and toxicities of a combination of fosfomycin (FOM) and clavulanic acid/ticarcillin (CVA/TIPC) for treatment of infections complicated with hematolagical disorders in 61 patients. Fifty-eight patients were evaluable, including 40 with acute leukemia, 13 with malignant lymphoma and 5 with other hematological disorders. Clinical efficacies were excellent in 21 cases, good in 13 cases, fair in 2 cases and poor in 22 cases. The efficacy rate was 58.6% (34 cases/58 cases). This treatment was also effective in 12 of 20 cases in which granulocyte counts were less than 500/μ1 through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 1 case. Mild elevations of GOT and GPT were observed. Thus, the combination of FOM and CVA/TIPC is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders.

Original languageEnglish (US)
Pages (from-to)521-529
Number of pages9
JournalThe Japanese Journal of Antibiotics
Volume47
Issue number5
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Clinical effects of a combination treatment with fosfomycin and clavulanic acid/ticarcillin for infections in patients complicated with hematological disorders'. Together they form a unique fingerprint.

Cite this