Clinical effects of a combination treatment with fosfomycin and clavulanic acid/ticarcillin for infections in patients complicated with hematological disorders

Kouichi Hirakawa; Shouichirou Tsuda; Shinichi Misawa; Yutaka Ueda; Hiroto Kaneko; Makoto Nakao; Yuko Ariyama; Hiroyuki Nakai; Taku Seriu; Teruyuki Takashima; Shinji Tanaka; Hikari Nishigaki; Shouhei Yokota; Shigeo Horiike; Masashi Taniwaki; Kei Kashima

doi:10.11553/antibiotics1968b.47.521

Clinical effects of a combination treatment with fosfomycin and clavulanic acid/ticarcillin for infections in patients complicated with hematological disorders

Kouichi Hirakawa, Shouichirou Tsuda, Shinichi Misawa, Yutaka Ueda, Hiroto Kaneko, Makoto Nakao, Yuko Ariyama, Hiroyuki Nakai, Taku Seriu, Teruyuki Takashima, Shinji Tanaka, Hikari Nishigaki, Shouhei Yokota, Shigeo Horiike, Masashi Taniwaki, Kei Kashima

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Abstract

We evaluated clinical effects and toxicities of a combination of fosfomycin (FOM) and clavulanic acid/ticarcillin (CVA/TIPC) for treatment of infections complicated with hematolagical disorders in 61 patients. Fifty-eight patients were evaluable, including 40 with acute leukemia, 13 with malignant lymphoma and 5 with other hematological disorders. Clinical efficacies were excellent in 21 cases, good in 13 cases, fair in 2 cases and poor in 22 cases. The efficacy rate was 58.6% (34 cases/58 cases). This treatment was also effective in 12 of 20 cases in which granulocyte counts were less than 500/μ1 through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 1 case. Mild elevations of GOT and GPT were observed. Thus, the combination of FOM and CVA/TIPC is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders.

Original language	English (US)
Pages (from-to)	521-529
Number of pages	9
Journal	The Japanese Journal of Antibiotics
Volume	47
Issue number	5
DOIs	https://doi.org/10.11553/antibiotics1968b.47.521
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

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Hirakawa, K., Tsuda, S., Misawa, S., Ueda, Y., Kaneko, H., Nakao, M., Ariyama, Y., Nakai, H., Seriu, T., Takashima, T., Tanaka, S., Nishigaki, H., Yokota, S., Horiike, S., Taniwaki, M., & Kashima, K. (1994). Clinical effects of a combination treatment with fosfomycin and clavulanic acid/ticarcillin for infections in patients complicated with hematological disorders. The Japanese Journal of Antibiotics, 47(5), 521-529. https://doi.org/10.11553/antibiotics1968b.47.521

Hirakawa, K, Tsuda, S, Misawa, S, Ueda, Y, Kaneko, H, Nakao, M, Ariyama, Y, Nakai, H, Seriu, T, Takashima, T, Tanaka, S, Nishigaki, H, Yokota, S, Horiike, S, Taniwaki, M & Kashima, K 1994, 'Clinical effects of a combination treatment with fosfomycin and clavulanic acid/ticarcillin for infections in patients complicated with hematological disorders', The Japanese Journal of Antibiotics, vol. 47, no. 5, pp. 521-529. https://doi.org/10.11553/antibiotics1968b.47.521

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title = "Clinical effects of a combination treatment with fosfomycin and clavulanic acid/ticarcillin for infections in patients complicated with hematological disorders",

abstract = "We evaluated clinical effects and toxicities of a combination of fosfomycin (FOM) and clavulanic acid/ticarcillin (CVA/TIPC) for treatment of infections complicated with hematolagical disorders in 61 patients. Fifty-eight patients were evaluable, including 40 with acute leukemia, 13 with malignant lymphoma and 5 with other hematological disorders. Clinical efficacies were excellent in 21 cases, good in 13 cases, fair in 2 cases and poor in 22 cases. The efficacy rate was 58.6% (34 cases/58 cases). This treatment was also effective in 12 of 20 cases in which granulocyte counts were less than 500/μ1 through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 1 case. Mild elevations of GOT and GPT were observed. Thus, the combination of FOM and CVA/TIPC is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders.",

author = "Kouichi Hirakawa and Shouichirou Tsuda and Shinichi Misawa and Yutaka Ueda and Hiroto Kaneko and Makoto Nakao and Yuko Ariyama and Hiroyuki Nakai and Taku Seriu and Teruyuki Takashima and Shinji Tanaka and Hikari Nishigaki and Shouhei Yokota and Shigeo Horiike and Masashi Taniwaki and Kei Kashima",

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AU - Hirakawa, Kouichi

AU - Tsuda, Shouichirou

AU - Misawa, Shinichi

AU - Ueda, Yutaka

AU - Kaneko, Hiroto

AU - Nakao, Makoto

AU - Ariyama, Yuko

AU - Nakai, Hiroyuki

AU - Seriu, Taku

AU - Takashima, Teruyuki

AU - Tanaka, Shinji

AU - Nishigaki, Hikari

AU - Yokota, Shouhei

AU - Horiike, Shigeo

AU - Taniwaki, Masashi

AU - Kashima, Kei

PY - 1994

Y1 - 1994

N2 - We evaluated clinical effects and toxicities of a combination of fosfomycin (FOM) and clavulanic acid/ticarcillin (CVA/TIPC) for treatment of infections complicated with hematolagical disorders in 61 patients. Fifty-eight patients were evaluable, including 40 with acute leukemia, 13 with malignant lymphoma and 5 with other hematological disorders. Clinical efficacies were excellent in 21 cases, good in 13 cases, fair in 2 cases and poor in 22 cases. The efficacy rate was 58.6% (34 cases/58 cases). This treatment was also effective in 12 of 20 cases in which granulocyte counts were less than 500/μ1 through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 1 case. Mild elevations of GOT and GPT were observed. Thus, the combination of FOM and CVA/TIPC is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders.

AB - We evaluated clinical effects and toxicities of a combination of fosfomycin (FOM) and clavulanic acid/ticarcillin (CVA/TIPC) for treatment of infections complicated with hematolagical disorders in 61 patients. Fifty-eight patients were evaluable, including 40 with acute leukemia, 13 with malignant lymphoma and 5 with other hematological disorders. Clinical efficacies were excellent in 21 cases, good in 13 cases, fair in 2 cases and poor in 22 cases. The efficacy rate was 58.6% (34 cases/58 cases). This treatment was also effective in 12 of 20 cases in which granulocyte counts were less than 500/μ1 through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 1 case. Mild elevations of GOT and GPT were observed. Thus, the combination of FOM and CVA/TIPC is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders.

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Clinical effects of a combination treatment with fosfomycin and clavulanic acid/ticarcillin for infections in patients complicated with hematological disorders

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