TY - CHAP
T1 - Clinical Dilemmas in Anticoagulation
T2 - Extremes of Weight, Renal Disease, Recent Bleeding, and Surgery
AU - DeLoughery, Thomas G.
N1 - Funding Information:
The work reviewed in this paper would not have been possible without the invaluable contributions by Dr E. Alekseev, A. Manasson, G. Eadara, K. Mutamba and O. Yilmazoglu who performed extensive theoretical and experimental studies on GaN-based NDR devices. Thanks are also due to S. Hubbard and W. Sutton for device processing, Dr J. East for mm-wave packaging and testing help, Dr K. Tomizawa for theoretical considerations and Dr M. Wraback for helpful comments. The support and continuous encouragement by Drs C. Wood, J. Zolper, E. Martinez and H. Dietrich is greatly acknowledged. Work supported by ONR (Contract No. N00014-92-J-1552 and Contract No. N00014-01-1-0902) and DARPA/ONR (Contract No. N00014-99-1-0513).
Publisher Copyright:
© Springer Nature Switzerland AG 2019.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Clinical trials of antithrombotic agents enrolled thousands of patients and form the basis of current recommendations for therapy. However, many patients with thrombosis were not adequately represented in clinical trials. These would include patients at extremes of weight, those with renal disease, those with recent bleeding, and those who need surgery. This chapter reviews many challenging clinical situations such as anticoagulation in those with renal disease and restarting anticoagulation after bleeding. Recommendations are made based on the limited data available.
AB - Clinical trials of antithrombotic agents enrolled thousands of patients and form the basis of current recommendations for therapy. However, many patients with thrombosis were not adequately represented in clinical trials. These would include patients at extremes of weight, those with renal disease, those with recent bleeding, and those who need surgery. This chapter reviews many challenging clinical situations such as anticoagulation in those with renal disease and restarting anticoagulation after bleeding. Recommendations are made based on the limited data available.
KW - Antithrombotic therapy
KW - Direct oral anticoagulants
KW - Pregnancy
KW - Renal disease
UR - http://www.scopus.com/inward/record.url?scp=85106509125&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85106509125&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-19330-0_28
DO - 10.1007/978-3-030-19330-0_28
M3 - Chapter
AN - SCOPUS:85106509125
SN - 9783030193294
SP - 179
EP - 185
BT - Hemostasis and Thrombosis
PB - Springer International Publishing
ER -