Clinical correlations of serial quantitative blood cultures determined by lysis-centrifugation in patients with persistent septicemia

E. Whimbey, Brian Wong, T. E. Kiehn, D. Armstrong

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The potential clinical value of colony counts determined by the lysis-centrifugation blood culture method was studied by reviewing the records of eight patients with persistent septicemia in whom colony counts were available on at least 3 days. Colony counts of the five patients who survived decreased steadily as the patients improved. One of the three patients who died had counts repeatedly below 1.0 CFU/ml while she was clinically stable and higher counts when her condition deteriorated. Two patients died despite decreasing colony counts. One was improving and died unexpectedly of an unrelated cause; the other died of candidiasis, but declining serial arabinitol/creatinine ratios suggested a partial response to therapy. In addition, septicemia related to infected intravenous catheters was documented by demonstrating large differences in colony counts determined simultaneously from two different sites in two patients and by demonstrating a precipitous drop in CFU per milliliter after removal of the infected catheter in one patient. Routine availability of colony counts appears to be an important advantage of the lysis-centrifugation method.

Original languageEnglish (US)
Pages (from-to)766-771
Number of pages6
JournalJournal of Clinical Microbiology
Volume19
Issue number6
StatePublished - 1984
Externally publishedYes

Fingerprint

Centrifugation
Sepsis
Catheters
Candidiasis
Blood Culture
Creatinine

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Clinical correlations of serial quantitative blood cultures determined by lysis-centrifugation in patients with persistent septicemia. / Whimbey, E.; Wong, Brian; Kiehn, T. E.; Armstrong, D.

In: Journal of Clinical Microbiology, Vol. 19, No. 6, 1984, p. 766-771.

Research output: Contribution to journalArticle

@article{469f6f44e1f14c0eb13e53a2c991ebcb,
title = "Clinical correlations of serial quantitative blood cultures determined by lysis-centrifugation in patients with persistent septicemia",
abstract = "The potential clinical value of colony counts determined by the lysis-centrifugation blood culture method was studied by reviewing the records of eight patients with persistent septicemia in whom colony counts were available on at least 3 days. Colony counts of the five patients who survived decreased steadily as the patients improved. One of the three patients who died had counts repeatedly below 1.0 CFU/ml while she was clinically stable and higher counts when her condition deteriorated. Two patients died despite decreasing colony counts. One was improving and died unexpectedly of an unrelated cause; the other died of candidiasis, but declining serial arabinitol/creatinine ratios suggested a partial response to therapy. In addition, septicemia related to infected intravenous catheters was documented by demonstrating large differences in colony counts determined simultaneously from two different sites in two patients and by demonstrating a precipitous drop in CFU per milliliter after removal of the infected catheter in one patient. Routine availability of colony counts appears to be an important advantage of the lysis-centrifugation method.",
author = "E. Whimbey and Brian Wong and Kiehn, {T. E.} and D. Armstrong",
year = "1984",
language = "English (US)",
volume = "19",
pages = "766--771",
journal = "Journal of Clinical Microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "6",

}

TY - JOUR

T1 - Clinical correlations of serial quantitative blood cultures determined by lysis-centrifugation in patients with persistent septicemia

AU - Whimbey, E.

AU - Wong, Brian

AU - Kiehn, T. E.

AU - Armstrong, D.

PY - 1984

Y1 - 1984

N2 - The potential clinical value of colony counts determined by the lysis-centrifugation blood culture method was studied by reviewing the records of eight patients with persistent septicemia in whom colony counts were available on at least 3 days. Colony counts of the five patients who survived decreased steadily as the patients improved. One of the three patients who died had counts repeatedly below 1.0 CFU/ml while she was clinically stable and higher counts when her condition deteriorated. Two patients died despite decreasing colony counts. One was improving and died unexpectedly of an unrelated cause; the other died of candidiasis, but declining serial arabinitol/creatinine ratios suggested a partial response to therapy. In addition, septicemia related to infected intravenous catheters was documented by demonstrating large differences in colony counts determined simultaneously from two different sites in two patients and by demonstrating a precipitous drop in CFU per milliliter after removal of the infected catheter in one patient. Routine availability of colony counts appears to be an important advantage of the lysis-centrifugation method.

AB - The potential clinical value of colony counts determined by the lysis-centrifugation blood culture method was studied by reviewing the records of eight patients with persistent septicemia in whom colony counts were available on at least 3 days. Colony counts of the five patients who survived decreased steadily as the patients improved. One of the three patients who died had counts repeatedly below 1.0 CFU/ml while she was clinically stable and higher counts when her condition deteriorated. Two patients died despite decreasing colony counts. One was improving and died unexpectedly of an unrelated cause; the other died of candidiasis, but declining serial arabinitol/creatinine ratios suggested a partial response to therapy. In addition, septicemia related to infected intravenous catheters was documented by demonstrating large differences in colony counts determined simultaneously from two different sites in two patients and by demonstrating a precipitous drop in CFU per milliliter after removal of the infected catheter in one patient. Routine availability of colony counts appears to be an important advantage of the lysis-centrifugation method.

UR - http://www.scopus.com/inward/record.url?scp=0021268187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021268187&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 766

EP - 771

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 6

ER -