Clinical correlations of serial quantitative blood cultures determined by lysis-centrifugation in patients with persistent septicemia

E. Whimbey, B. Wong, T. E. Kiehn, D. Armstrong

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

The potential clinical value of colony counts determined by the lysis-centrifugation blood culture method was studied by reviewing the records of eight patients with persistent septicemia in whom colony counts were available on at least 3 days. Colony counts of the five patients who survived decreased steadily as the patients improved. One of the three patients who died had counts repeatedly below 1.0 CFU/ml while she was clinically stable and higher counts when her condition deteriorated. Two patients died despite decreasing colony counts. One was improving and died unexpectedly of an unrelated cause; the other died of candidiasis, but declining serial arabinitol/creatinine ratios suggested a partial response to therapy. In addition, septicemia related to infected intravenous catheters was documented by demonstrating large differences in colony counts determined simultaneously from two different sites in two patients and by demonstrating a precipitous drop in CFU per milliliter after removal of the infected catheter in one patient. Routine availability of colony counts appears to be an important advantage of the lysis-centrifugation method.

Original languageEnglish (US)
Pages (from-to)766-771
Number of pages6
JournalJournal of Clinical Microbiology
Volume19
Issue number6
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Microbiology (medical)

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