Clinical correlates of red blood cell omega-3 fatty acid content in male veterans with peripheral arterial disease

Emily V. Nosova, Karen C. Chong, Hugh F. Alley, William Harris, W. John Boscardin, Michael S. Conte, Christopher D. Owens, S. Marlene Grenon

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective: Despite available medical therapies, patients with peripheral arterial disease (PAD) remain at high risk for cardiovascular events. The n-3 polyunsaturated fatty acids (PUFA), derived from marine sources, have been shown to improve cardiovascular mortality. The Omega-3 Index (O3I), a proportion of the n-3 PUFA eicosapentaenoic acid and docosahexaenoic acid in the red blood cell membrane, correlates with cardiovascular risk. Previous investigations have found that n-3 PUFA supplementation, fish consumption, older age, and smoking history affect the O3I in different patient populations, although similar correlations have never been explored in PAD. We hypothesized that in our PADcohort, blood content of omega-3 fatty acids would directly and positively correlate with a history of fish oil supplementation and older age and inversely correlate with a smoking history and obesity. Methods: This cross-sectional study included 111 patients who had an ankle-brachial index of

Original languageEnglish (US)
Pages (from-to)1325-1331
Number of pages7
JournalJournal of Vascular Surgery
Volume60
Issue number5
DOIs
Publication statusPublished - 2014
Externally publishedYes

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Nosova, E. V., Chong, K. C., Alley, H. F., Harris, W., Boscardin, W. J., Conte, M. S., ... Grenon, S. M. (2014). Clinical correlates of red blood cell omega-3 fatty acid content in male veterans with peripheral arterial disease. Journal of Vascular Surgery, 60(5), 1325-1331. https://doi.org/10.1016/j.jvs.2014.05.040