Clinical characteristics predict response to antithymocyte globulin in paroxysmal nocturnal haemoglobinuria

Ronald L. Paquette, Ryan Yoshimura, Charles Veiseh, Lori Kunkel, James Gajewski, Peter J. Rosen

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Seven patients with paroxysmal nocturnal haemoglobinuria (PNH) were treated with antithymocyte globulin (ATG). Each patient received ATG (20 mg/kg/d) for 8 d and prednisone to prevent or control serum sickness. Three patients experienced a sustained improvement in at least one peripheral blood cytopenia, including one patient who had a complete trilineage response. Several pretreatment clinical features appeared to be associated with response to ATG. All responding patients had hypoproliferative features including depressed platelet counts (9/l), and a minor degree of chronic haemolysis as indicated by relatively low reticulocyte counts (9/l), lactate dehydrogenase (100 x 109/l), lactate dehydrogenase (>2000 U/l) and total bilirubin (>17 μmol/l) levels. The impaired haemopoiesis that occurs in hypoproliferative PNH may respond to ATG treatment, but the haemolytic component of the disease, and hence the PNH clone, is not altered by immunosuppressive therapy.

Original languageEnglish (US)
Pages (from-to)92-97
Number of pages6
JournalBritish Journal of Haematology
Volume96
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

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Paroxysmal Hemoglobinuria
Antilymphocyte Serum
L-Lactate Dehydrogenase
Serum Sickness
Reticulocyte Count
Immunosuppressive Agents
Prednisone
Hemolysis
Platelet Count
Bilirubin
Clone Cells
Therapeutics

Keywords

  • antithymocyte globulin
  • aplastic anaemia
  • immunosuppressive therapy
  • paroxysmal nocturnal haemoglobinuria

ASJC Scopus subject areas

  • Hematology

Cite this

Clinical characteristics predict response to antithymocyte globulin in paroxysmal nocturnal haemoglobinuria. / Paquette, Ronald L.; Yoshimura, Ryan; Veiseh, Charles; Kunkel, Lori; Gajewski, James; Rosen, Peter J.

In: British Journal of Haematology, Vol. 96, No. 1, 1997, p. 92-97.

Research output: Contribution to journalArticle

Paquette, Ronald L. ; Yoshimura, Ryan ; Veiseh, Charles ; Kunkel, Lori ; Gajewski, James ; Rosen, Peter J. / Clinical characteristics predict response to antithymocyte globulin in paroxysmal nocturnal haemoglobinuria. In: British Journal of Haematology. 1997 ; Vol. 96, No. 1. pp. 92-97.
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