Clinical characteristics of acanthamoeba keratitis infections in 28 states, 2008 to 2011

Jonathan Ross, Sharon L. Roy, William Mathers, David C. Ritterband, Jonathan S. Yoder, Tracy Ayers, Rupa D. Shah, Monika E. Samper, Carolyn Y. Shih, Ann Schmitz, Allison C. Brown

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

PURPOSE:: The aim was to describe a geographically and clinically diverse sample of cases of Acanthamoeba keratitis (AK) and establish the risk factors for poor outcomes among patients with this disease. METHODS:: We conducted a retrospective, population-based case series of 116 patients with AK identified through a national surveillance network. Data were collected via a medical record review by diagnosing ophthalmologists and by phone interviews with patients. Exact logistic regression modeling was used to determine risk factors for poor visual outcomes. RESULTS:: Among patients with data available on contact lens use, it was found that 93.3% wore contact lenses. The median time from symptom onset to care seeking was 2 days, whereas the median time from symptom onset to diagnosis was 27 days. Keratoplasty was performed in 27 of 81 patients with available outcome data and was more likely in patients >40 years old [odds ratio (OR) 5.25, 95% confidence interval (CI) 1.49-21.92]. When adjusted for age, the risk factors for keratoplasty included the presence of a ring infiltrate (OR 40.00, 95% CI 3.58-447.0) or any sign of stromal invasion (OR 10.48, 95% CI 2.56-55.09). One-third of patients with available data on best-corrected visual acuity had a best-corrected visual acuity

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalCornea
Volume33
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

Acanthamoeba Keratitis
Infection
Corneal Transplantation
Odds Ratio
Contact Lenses
Confidence Intervals
Visual Acuity
Age Factors
Medical Records
Logistic Models
Interviews

Keywords

  • Acanthamoeba
  • Diagnosis
  • Risk factors

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ross, J., Roy, S. L., Mathers, W., Ritterband, D. C., Yoder, J. S., Ayers, T., ... Brown, A. C. (2014). Clinical characteristics of acanthamoeba keratitis infections in 28 states, 2008 to 2011. Cornea, 33(2), 161-168. https://doi.org/10.1097/ICO.0000000000000014

Clinical characteristics of acanthamoeba keratitis infections in 28 states, 2008 to 2011. / Ross, Jonathan; Roy, Sharon L.; Mathers, William; Ritterband, David C.; Yoder, Jonathan S.; Ayers, Tracy; Shah, Rupa D.; Samper, Monika E.; Shih, Carolyn Y.; Schmitz, Ann; Brown, Allison C.

In: Cornea, Vol. 33, No. 2, 02.2014, p. 161-168.

Research output: Contribution to journalArticle

Ross, J, Roy, SL, Mathers, W, Ritterband, DC, Yoder, JS, Ayers, T, Shah, RD, Samper, ME, Shih, CY, Schmitz, A & Brown, AC 2014, 'Clinical characteristics of acanthamoeba keratitis infections in 28 states, 2008 to 2011', Cornea, vol. 33, no. 2, pp. 161-168. https://doi.org/10.1097/ICO.0000000000000014
Ross, Jonathan ; Roy, Sharon L. ; Mathers, William ; Ritterband, David C. ; Yoder, Jonathan S. ; Ayers, Tracy ; Shah, Rupa D. ; Samper, Monika E. ; Shih, Carolyn Y. ; Schmitz, Ann ; Brown, Allison C. / Clinical characteristics of acanthamoeba keratitis infections in 28 states, 2008 to 2011. In: Cornea. 2014 ; Vol. 33, No. 2. pp. 161-168.
@article{36635ff2742641b297a647eea701b20d,
title = "Clinical characteristics of acanthamoeba keratitis infections in 28 states, 2008 to 2011",
abstract = "PURPOSE:: The aim was to describe a geographically and clinically diverse sample of cases of Acanthamoeba keratitis (AK) and establish the risk factors for poor outcomes among patients with this disease. METHODS:: We conducted a retrospective, population-based case series of 116 patients with AK identified through a national surveillance network. Data were collected via a medical record review by diagnosing ophthalmologists and by phone interviews with patients. Exact logistic regression modeling was used to determine risk factors for poor visual outcomes. RESULTS:: Among patients with data available on contact lens use, it was found that 93.3{\%} wore contact lenses. The median time from symptom onset to care seeking was 2 days, whereas the median time from symptom onset to diagnosis was 27 days. Keratoplasty was performed in 27 of 81 patients with available outcome data and was more likely in patients >40 years old [odds ratio (OR) 5.25, 95{\%} confidence interval (CI) 1.49-21.92]. When adjusted for age, the risk factors for keratoplasty included the presence of a ring infiltrate (OR 40.00, 95{\%} CI 3.58-447.0) or any sign of stromal invasion (OR 10.48, 95{\%} CI 2.56-55.09). One-third of patients with available data on best-corrected visual acuity had a best-corrected visual acuity",
keywords = "Acanthamoeba, Diagnosis, Risk factors",
author = "Jonathan Ross and Roy, {Sharon L.} and William Mathers and Ritterband, {David C.} and Yoder, {Jonathan S.} and Tracy Ayers and Shah, {Rupa D.} and Samper, {Monika E.} and Shih, {Carolyn Y.} and Ann Schmitz and Brown, {Allison C.}",
year = "2014",
month = "2",
doi = "10.1097/ICO.0000000000000014",
language = "English (US)",
volume = "33",
pages = "161--168",
journal = "Cornea",
issn = "0277-3740",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Clinical characteristics of acanthamoeba keratitis infections in 28 states, 2008 to 2011

AU - Ross, Jonathan

AU - Roy, Sharon L.

AU - Mathers, William

AU - Ritterband, David C.

AU - Yoder, Jonathan S.

AU - Ayers, Tracy

AU - Shah, Rupa D.

AU - Samper, Monika E.

AU - Shih, Carolyn Y.

AU - Schmitz, Ann

AU - Brown, Allison C.

PY - 2014/2

Y1 - 2014/2

N2 - PURPOSE:: The aim was to describe a geographically and clinically diverse sample of cases of Acanthamoeba keratitis (AK) and establish the risk factors for poor outcomes among patients with this disease. METHODS:: We conducted a retrospective, population-based case series of 116 patients with AK identified through a national surveillance network. Data were collected via a medical record review by diagnosing ophthalmologists and by phone interviews with patients. Exact logistic regression modeling was used to determine risk factors for poor visual outcomes. RESULTS:: Among patients with data available on contact lens use, it was found that 93.3% wore contact lenses. The median time from symptom onset to care seeking was 2 days, whereas the median time from symptom onset to diagnosis was 27 days. Keratoplasty was performed in 27 of 81 patients with available outcome data and was more likely in patients >40 years old [odds ratio (OR) 5.25, 95% confidence interval (CI) 1.49-21.92]. When adjusted for age, the risk factors for keratoplasty included the presence of a ring infiltrate (OR 40.00, 95% CI 3.58-447.0) or any sign of stromal invasion (OR 10.48, 95% CI 2.56-55.09). One-third of patients with available data on best-corrected visual acuity had a best-corrected visual acuity

AB - PURPOSE:: The aim was to describe a geographically and clinically diverse sample of cases of Acanthamoeba keratitis (AK) and establish the risk factors for poor outcomes among patients with this disease. METHODS:: We conducted a retrospective, population-based case series of 116 patients with AK identified through a national surveillance network. Data were collected via a medical record review by diagnosing ophthalmologists and by phone interviews with patients. Exact logistic regression modeling was used to determine risk factors for poor visual outcomes. RESULTS:: Among patients with data available on contact lens use, it was found that 93.3% wore contact lenses. The median time from symptom onset to care seeking was 2 days, whereas the median time from symptom onset to diagnosis was 27 days. Keratoplasty was performed in 27 of 81 patients with available outcome data and was more likely in patients >40 years old [odds ratio (OR) 5.25, 95% confidence interval (CI) 1.49-21.92]. When adjusted for age, the risk factors for keratoplasty included the presence of a ring infiltrate (OR 40.00, 95% CI 3.58-447.0) or any sign of stromal invasion (OR 10.48, 95% CI 2.56-55.09). One-third of patients with available data on best-corrected visual acuity had a best-corrected visual acuity

KW - Acanthamoeba

KW - Diagnosis

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=84892993815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892993815&partnerID=8YFLogxK

U2 - 10.1097/ICO.0000000000000014

DO - 10.1097/ICO.0000000000000014

M3 - Article

VL - 33

SP - 161

EP - 168

JO - Cornea

JF - Cornea

SN - 0277-3740

IS - 2

ER -