Clinical characteristics and predictors of mortality in 67 patients with primary pyomyositis: A study from North India

Aman Sharma, Susheel Kumar, Ajay Wanchu, Kusum Sharma, Navneet Sharma, Rajinder Singh, Pradeep Bambery, Surjit Singh, Subhash Varma

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Primary pyomyositis is infection of the skeletal muscles in the absence of adjacent skin, soft tissue, and bone infection. This study was undertaken to look at the spectrum of clinical presentations, therapeutic interventions, and their outcomes and also to evaluate the association of various risk factors with mortality. This was a retrospective study in which the patients admitted with the diagnosis of primary pyomyositis from January 2000 to June 2007 were included. Their demographic details, clinical and laboratory data, Sequential Organ Failure Assessment (SOFA) score at presentation, treatment instituted, complications encountered, and hospital outcome were recorded. Sixty-seven patients (42 males and 25 females) with a diagnosis of primary pyomyositis were included. Median age at the time of presentation was 37 years (interquartile range=25-50 years). Common presenting symptoms were myalgias [50 (74.62%)] and fever [49 (73.13%)]. Twenty-six patients had underlying predisposing medical conditions. The commonest muscle group involved was iliopsoas muscles in 31 (46.26%) patients. Methicillin-sensitive Staphylococcus aureus was the commonest organism isolated from the pus. Twenty-eight patients developed sepsis and seven died. On univariate analysis, there was a statistically significant association between higher SOFA score, lower Glasgow coma scale, higher pulse rate, lower blood pressure, raised blood urea, raised serum creatinine, higher serum glutamic pyruvate transaminase, raised total bilirubin at presentation, and development of sepsis during hospital stay with mortality. In our study, the patients were seen almost a decade later than those seen in other studies from the region. Evidence of organ dysfunction at presentation and sepsis was associated with increased mortality.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalClinical Rheumatology
Volume29
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Fingerprint

Pyomyositis
India
Mortality
Organ Dysfunction Scores
Sepsis
Muscles
Soft Tissue Infections
Glasgow Coma Scale
Methicillin
Suppuration
Myalgia
Transaminases
Serum
Pyruvic Acid
Bilirubin
Urea
Staphylococcus aureus
Length of Stay
Creatinine
Skeletal Muscle

Keywords

  • India
  • Mortality
  • Primary pyomyositis
  • Sepsis
  • SOFA score

ASJC Scopus subject areas

  • Rheumatology

Cite this

Clinical characteristics and predictors of mortality in 67 patients with primary pyomyositis : A study from North India. / Sharma, Aman; Kumar, Susheel; Wanchu, Ajay; Sharma, Kusum; Sharma, Navneet; Singh, Rajinder; Bambery, Pradeep; Singh, Surjit; Varma, Subhash.

In: Clinical Rheumatology, Vol. 29, No. 1, 01.2010, p. 45-51.

Research output: Contribution to journalArticle

Sharma, A, Kumar, S, Wanchu, A, Sharma, K, Sharma, N, Singh, R, Bambery, P, Singh, S & Varma, S 2010, 'Clinical characteristics and predictors of mortality in 67 patients with primary pyomyositis: A study from North India', Clinical Rheumatology, vol. 29, no. 1, pp. 45-51. https://doi.org/10.1007/s10067-009-1277-x
Sharma, Aman ; Kumar, Susheel ; Wanchu, Ajay ; Sharma, Kusum ; Sharma, Navneet ; Singh, Rajinder ; Bambery, Pradeep ; Singh, Surjit ; Varma, Subhash. / Clinical characteristics and predictors of mortality in 67 patients with primary pyomyositis : A study from North India. In: Clinical Rheumatology. 2010 ; Vol. 29, No. 1. pp. 45-51.
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