Clinical behavior and a contemporary management algorithm for prepubertal testis tumors: A summary of the prepubertal testis tumor registry

Jonathan H. Ross, Lisa Rybicki, Robert Kay, Michael Ritchey, Jonathan Ross, Steven Skoog, Douglas Canning, George Kaplan

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Purpose: The Prepubertal Testis Tumor Registry was established by the Urologic Section of the American Academy of Pediatrics in 1980 to record data on a large number of prepubertal testis tumors regarding presentation, treatment and outcome to define appropriate management better. We reviewed the registry data in the context of other modern studies to elucidate the appropriate management of these rare tumors. Materials and Methods: Relevant data in the prepubertal testis tumor registry were tabulated and analyzed. Results: There were 395 prepubertal patients who had a primary testis tumor. Generally benign tumors accounted for 38% of cases. A significant proportion of tumors were benign regardless of patient age. α-Fetoprotein levels for patients with benign and malignant tumors overlapped in children younger than 6 months. Of the patients with yolk sac tumor 80% presented with stage 1 disease and overall survival was excellent. There were no metastases or deaths among the patients with teratoma. Of all patients with stromal tumors metastases developed in only 1. Conclusions: We recommend initial excisional biopsy for all amenable prepubertal testis tumors, except those with an α-fetoprotein level that is clearly increased for patient age. Patients with benign tumors may be released from oncological followup. Patients with stage I yolk sac tumor should be monitored closely, and those with recurrent or metastatic yolk sac tumor should be treated with chemotherapy. Retroperitoneal lymph node dissection is reserved for patients with recurrent retroperitoneal masses following chemotherapy. Aggressive treatment of metastatic Sertoli cell or undifferentiated stromal tumors is warranted.

Original languageEnglish (US)
Pages (from-to)1675-1679
Number of pages5
JournalJournal of Urology
Volume168
Issue number4 II
StatePublished - Oct 2002
Externally publishedYes

Fingerprint

Registries
Testis
Neoplasms
Endodermal Sinus Tumor
Fetal Proteins
Neoplasm Metastasis
Drug Therapy
Sertoli Cells
Teratoma
Lymph Node Excision
Pediatrics
Biopsy
Survival

Keywords

  • Endodermal sinus tumor
  • Pediatrics
  • Testicular neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Clinical behavior and a contemporary management algorithm for prepubertal testis tumors : A summary of the prepubertal testis tumor registry. / Ross, Jonathan H.; Rybicki, Lisa; Kay, Robert; Ritchey, Michael; Ross, Jonathan; Skoog, Steven; Canning, Douglas; Kaplan, George.

In: Journal of Urology, Vol. 168, No. 4 II, 10.2002, p. 1675-1679.

Research output: Contribution to journalArticle

Ross, JH, Rybicki, L, Kay, R, Ritchey, M, Ross, J, Skoog, S, Canning, D & Kaplan, G 2002, 'Clinical behavior and a contemporary management algorithm for prepubertal testis tumors: A summary of the prepubertal testis tumor registry', Journal of Urology, vol. 168, no. 4 II, pp. 1675-1679.
Ross, Jonathan H. ; Rybicki, Lisa ; Kay, Robert ; Ritchey, Michael ; Ross, Jonathan ; Skoog, Steven ; Canning, Douglas ; Kaplan, George. / Clinical behavior and a contemporary management algorithm for prepubertal testis tumors : A summary of the prepubertal testis tumor registry. In: Journal of Urology. 2002 ; Vol. 168, No. 4 II. pp. 1675-1679.
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