CLINICAL, BACTERIOLOGICAL, AND IMMUNOLOGICAL CHARACTERISATION OF AMPICILLIN-RESISTANT HÆMOPHILUS INFLUENZÆ TYPE B

M. S. Schiffer; R. Schneerson; J. Maclowry; J. B. Robbins; J. W. Mcreynolds; W. J. Thomas; D. W. Bailey; E. J. Clarke; E. J. Mueller; J. Escamilla

doi:10.1016/S0140-6736(74)91416-0

CLINICAL, BACTERIOLOGICAL, AND IMMUNOLOGICAL CHARACTERISATION OF AMPICILLIN-RESISTANT HÆMOPHILUS INFLUENZÆ TYPE B

M. S. Schiffer, R. Schneerson, J. Maclowry, J. B. Robbins, J. W. Mcreynolds, W. J. Thomas, D. W. Bailey, E. J. Clarke, E. J. Mueller, J. Escamilla

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Abstract

Ampicillin-resistant Hæmophilus influenzæ type b (H.I.T.B.) was isolated from the cerebrospinal fluid of 1 of 3 children with H.I.T.B. meningitis, attending the same day-care centre. 81 children and 13 adults, from the same area as the 3 cases, were examined for nasopharyngeal carriage of H.I.T.B. Six ampicillin-resistant and four ampicillin-sensitive strains were recovered from the children. When 46 of these children were re-examined and had blood drawn one month later, 11 carriers of H.I.T.B. were found. High levels of H.I.T.B. antibody were associated with persistent carriage of either the ampicillin resistant or sensitive strains. All isolates from children at the day-care centre were ampicillin resistant during both surveys.

Original language	English (US)
Pages (from-to)	257-259
Number of pages	3
Journal	The Lancet
Volume	304
Issue number	7875
DOIs	https://doi.org/10.1016/S0140-6736(74)91416-0
State	Published - Aug 3 1974
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(74)91416-0

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@article{dcd72f7878f44d6a9ff7f3d942168484,

title = "CLINICAL, BACTERIOLOGICAL, AND IMMUNOLOGICAL CHARACTERISATION OF AMPICILLIN-RESISTANT H{\AE}MOPHILUS INFLUENZ{\AE} TYPE B",

abstract = "Ampicillin-resistant H{\ae}mophilus influenz{\ae} type b (H.I.T.B.) was isolated from the cerebrospinal fluid of 1 of 3 children with H.I.T.B. meningitis, attending the same day-care centre. 81 children and 13 adults, from the same area as the 3 cases, were examined for nasopharyngeal carriage of H.I.T.B. Six ampicillin-resistant and four ampicillin-sensitive strains were recovered from the children. When 46 of these children were re-examined and had blood drawn one month later, 11 carriers of H.I.T.B. were found. High levels of H.I.T.B. antibody were associated with persistent carriage of either the ampicillin resistant or sensitive strains. All isolates from children at the day-care centre were ampicillin resistant during both surveys.",

author = "Schiffer, {M. S.} and R. Schneerson and J. Maclowry and Robbins, {J. B.} and Mcreynolds, {J. W.} and Thomas, {W. J.} and Bailey, {D. W.} and Clarke, {E. J.} and Mueller, {E. J.} and J. Escamilla",

note = "Funding Information: We thank Prof. 1. D. P. Wootton for the results of routine liver-function tests, Mr Sindi Kapur for technical assistance, and Mrs Hazel Creed for typing the manuscript. We are grateful to Weddel Pharmaceuticals (G. D. B. and H. Y. I. M.) and to the Medical Research Council (R. H. D.) for their financial support. Weddel Pharmaceuticals supplied the C.D.C.A. Requests for reprints should be addressed to R. H. D., Gastroenterology Unit, Department of Medicine, Guy{\textquoteright}s Hos- pital Medical School, London SEI 9RT.",

year = "1974",

month = aug,

day = "3",

doi = "10.1016/S0140-6736(74)91416-0",

language = "English (US)",

volume = "304",

pages = "257--259",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "7875",

}

TY - JOUR

T1 - CLINICAL, BACTERIOLOGICAL, AND IMMUNOLOGICAL CHARACTERISATION OF AMPICILLIN-RESISTANT HÆMOPHILUS INFLUENZÆ TYPE B

AU - Schiffer, M. S.

AU - Schneerson, R.

AU - Maclowry, J.

AU - Robbins, J. B.

AU - Mcreynolds, J. W.

AU - Thomas, W. J.

AU - Bailey, D. W.

AU - Clarke, E. J.

AU - Mueller, E. J.

AU - Escamilla, J.

N1 - Funding Information: We thank Prof. 1. D. P. Wootton for the results of routine liver-function tests, Mr Sindi Kapur for technical assistance, and Mrs Hazel Creed for typing the manuscript. We are grateful to Weddel Pharmaceuticals (G. D. B. and H. Y. I. M.) and to the Medical Research Council (R. H. D.) for their financial support. Weddel Pharmaceuticals supplied the C.D.C.A. Requests for reprints should be addressed to R. H. D., Gastroenterology Unit, Department of Medicine, Guy’s Hos- pital Medical School, London SEI 9RT.

PY - 1974/8/3

Y1 - 1974/8/3

N2 - Ampicillin-resistant Hæmophilus influenzæ type b (H.I.T.B.) was isolated from the cerebrospinal fluid of 1 of 3 children with H.I.T.B. meningitis, attending the same day-care centre. 81 children and 13 adults, from the same area as the 3 cases, were examined for nasopharyngeal carriage of H.I.T.B. Six ampicillin-resistant and four ampicillin-sensitive strains were recovered from the children. When 46 of these children were re-examined and had blood drawn one month later, 11 carriers of H.I.T.B. were found. High levels of H.I.T.B. antibody were associated with persistent carriage of either the ampicillin resistant or sensitive strains. All isolates from children at the day-care centre were ampicillin resistant during both surveys.

AB - Ampicillin-resistant Hæmophilus influenzæ type b (H.I.T.B.) was isolated from the cerebrospinal fluid of 1 of 3 children with H.I.T.B. meningitis, attending the same day-care centre. 81 children and 13 adults, from the same area as the 3 cases, were examined for nasopharyngeal carriage of H.I.T.B. Six ampicillin-resistant and four ampicillin-sensitive strains were recovered from the children. When 46 of these children were re-examined and had blood drawn one month later, 11 carriers of H.I.T.B. were found. High levels of H.I.T.B. antibody were associated with persistent carriage of either the ampicillin resistant or sensitive strains. All isolates from children at the day-care centre were ampicillin resistant during both surveys.

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U2 - 10.1016/S0140-6736(74)91416-0

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IS - 7875

ER -

CLINICAL, BACTERIOLOGICAL, AND IMMUNOLOGICAL CHARACTERISATION OF AMPICILLIN-RESISTANT HÆMOPHILUS INFLUENZÆ TYPE B

Abstract

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