Ampicillin-resistant Hæmophilus influenzæ type b (H.I.T.B.) was isolated from the cerebrospinal fluid of 1 of 3 children with H.I.T.B. meningitis, attending the same day-care centre. 81 children and 13 adults, from the same area as the 3 cases, were examined for nasopharyngeal carriage of H.I.T.B. Six ampicillin-resistant and four ampicillin-sensitive strains were recovered from the children. When 46 of these children were re-examined and had blood drawn one month later, 11 carriers of H.I.T.B. were found. High levels of H.I.T.B. antibody were associated with persistent carriage of either the ampicillin resistant or sensitive strains. All isolates from children at the day-care centre were ampicillin resistant during both surveys.
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