Clinical applications of melatonin in circadian disorders

Alfred J. Lewy

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Chronobiological disorders and syndromes include seasonal affective disorder (SAD), total blindness, advanced and delayed sleep phase syndrome, jet lag, and shift work maladaptation. These disorders are treated by adjusting circadian phase, using appropriately timed bright light exposure and melatonin administration (at doses of 0.5 mg or less). In some cases, it may be necessary to measure internal circadian phase, using the time when endogenous melatonin levels rise.

Original languageEnglish (US)
Pages (from-to)399-413
Number of pages15
JournalDialogues in Clinical Neuroscience
Issue number4
StatePublished - Dec 1 2003


  • Circadian phase
  • Circadian sleep disorder
  • Jet lag
  • Melatonin
  • Seasonal affective disorder
  • Shift work
  • The blind

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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