Clinical applications of fluorescence in situ hybridization

D. C. Tkachuk, D. Pinkel, W. L. Kuo, H. U. Weier, J. W. Gray

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


We review here the application of fluorescence in situ hybridization with chromosome-specific probes to chromosome classification and to detection of changes in chromosome number or structure associated with genetic disease. Information is presented on probe types that are available for disease detection. We discuss the application of these probes to detection of numerical aberration important for prenatal diagnosis and to detection and characterization of numerical and structural aberrations in metaphase spreads and in interphase nuclei to facilitate tumor diagnosis.

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalGenetic Analysis: Biomolecular Engineering
Issue number2
StatePublished - Apr 1991
Externally publishedYes

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics


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