Clinical applications of fluorescence in situ hybridization

D. C. Tkachuk; D. Pinkel; W. L. Kuo; H. U. Weier; J. W. Gray

doi:10.1016/1050-3862(91)90051-R

Clinical applications of fluorescence in situ hybridization

D. C. Tkachuk, D. Pinkel, W. L. Kuo, H. U. Weier, J. W. Gray

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

We review here the application of fluorescence in situ hybridization with chromosome-specific probes to chromosome classification and to detection of changes in chromosome number or structure associated with genetic disease. Information is presented on probe types that are available for disease detection. We discuss the application of these probes to detection of numerical aberration important for prenatal diagnosis and to detection and characterization of numerical and structural aberrations in metaphase spreads and in interphase nuclei to facilitate tumor diagnosis.

Original language	English (US)
Pages (from-to)	67-74
Number of pages	8
Journal	Genetic Analysis: Biomolecular Engineering
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/1050-3862(91)90051-R
State	Published - Apr 1991
Externally published	Yes

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Genetics

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10.1016/1050-3862(91)90051-R

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title = "Clinical applications of fluorescence in situ hybridization",

abstract = "We review here the application of fluorescence in situ hybridization with chromosome-specific probes to chromosome classification and to detection of changes in chromosome number or structure associated with genetic disease. Information is presented on probe types that are available for disease detection. We discuss the application of these probes to detection of numerical aberration important for prenatal diagnosis and to detection and characterization of numerical and structural aberrations in metaphase spreads and in interphase nuclei to facilitate tumor diagnosis.",

author = "Tkachuk, {D. C.} and D. Pinkel and Kuo, {W. L.} and Weier, {H. U.} and Gray, {J. W.}",

note = "Funding Information: This work was performed under the auspices of the US Department of Energy by the Lawrence Livermore National Laboratory under contract W-7405-ENG-48, with support from USPHS grants CA 17665 and CA 45919.",

year = "1991",

month = apr,

doi = "10.1016/1050-3862(91)90051-R",

language = "English (US)",

volume = "8",

pages = "67--74",

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T1 - Clinical applications of fluorescence in situ hybridization

AU - Tkachuk, D. C.

AU - Pinkel, D.

AU - Kuo, W. L.

AU - Weier, H. U.

AU - Gray, J. W.

N1 - Funding Information: This work was performed under the auspices of the US Department of Energy by the Lawrence Livermore National Laboratory under contract W-7405-ENG-48, with support from USPHS grants CA 17665 and CA 45919.

PY - 1991/4

Y1 - 1991/4

N2 - We review here the application of fluorescence in situ hybridization with chromosome-specific probes to chromosome classification and to detection of changes in chromosome number or structure associated with genetic disease. Information is presented on probe types that are available for disease detection. We discuss the application of these probes to detection of numerical aberration important for prenatal diagnosis and to detection and characterization of numerical and structural aberrations in metaphase spreads and in interphase nuclei to facilitate tumor diagnosis.

AB - We review here the application of fluorescence in situ hybridization with chromosome-specific probes to chromosome classification and to detection of changes in chromosome number or structure associated with genetic disease. Information is presented on probe types that are available for disease detection. We discuss the application of these probes to detection of numerical aberration important for prenatal diagnosis and to detection and characterization of numerical and structural aberrations in metaphase spreads and in interphase nuclei to facilitate tumor diagnosis.

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JO - Genetic Analysis: Biomolecular Engineering

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ER -

Clinical applications of fluorescence in situ hybridization

Abstract

ASJC Scopus subject areas

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