Clinical and functional outcomes after 2 years in the early detection and intervention for the prevention of psychosis multisite effectiveness trial

William R. McFarlane, Bruce Levin, Lori Travis, F. Lee Lucas, Sarah Lynch, Mary Verdi, Deanna Williams, Steven Adelsheim, Roderick Calkins, Cameron S. Carter, Barbara Cornblatt, Stephan F. Taylor, Andrea M. Auther, Bentson McFarland, Ryan Melton, Margaret Migliorati, Tara Niendam, J. Daniel Ragland, Tamara Grace Sale, Melina SalvadorElizabeth Spring

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objective: To test effectiveness of the Early Detection, Intervention, and Prevention of Psychosis Program in preventing the onset of severe psychosis and improving functioning in a national sample of at-risk youth. Methods: In a risk-based allocation study design, 337 youth (age 12-25) at risk of psychosis were assigned to treatment groups based on severity of positive symptoms. Those at clinically higher risk (CHR) or having an early first episode of psychosis (EFEP) were assigned to receive Family-aided Assertive Community Treatment (FACT); those at clinically lower risk (CLR) were assigned to receive community care. Between-groups differences on outcome variables were adjusted statistically according to regression-discontinuity procedures and evaluated using the Global Test Procedure that combined all symptom and functional measures. Results: A total of 337 young people (mean age: 16.6) were assigned to the treatment group (CHR + EFEP, n = 250) or comparison group (CLR, n = 87). On the primary variable, positive symptoms, after 2 years FACT, were superior to community care (2 df, p

Original languageEnglish (US)
Pages (from-to)30-43
Number of pages14
JournalSchizophrenia Bulletin
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2015

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Psychotic Disorders
Community Mental Health Services
Therapeutics

Keywords

  • assertive community treatment
  • family psychoeducation
  • multifamily group
  • schizophrenia
  • supported education
  • supported employment

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Clinical and functional outcomes after 2 years in the early detection and intervention for the prevention of psychosis multisite effectiveness trial. / McFarlane, William R.; Levin, Bruce; Travis, Lori; Lucas, F. Lee; Lynch, Sarah; Verdi, Mary; Williams, Deanna; Adelsheim, Steven; Calkins, Roderick; Carter, Cameron S.; Cornblatt, Barbara; Taylor, Stephan F.; Auther, Andrea M.; McFarland, Bentson; Melton, Ryan; Migliorati, Margaret; Niendam, Tara; Ragland, J. Daniel; Sale, Tamara Grace; Salvador, Melina; Spring, Elizabeth.

In: Schizophrenia Bulletin, Vol. 41, No. 1, 01.01.2015, p. 30-43.

Research output: Contribution to journalArticle

McFarlane, WR, Levin, B, Travis, L, Lucas, FL, Lynch, S, Verdi, M, Williams, D, Adelsheim, S, Calkins, R, Carter, CS, Cornblatt, B, Taylor, SF, Auther, AM, McFarland, B, Melton, R, Migliorati, M, Niendam, T, Ragland, JD, Sale, TG, Salvador, M & Spring, E 2015, 'Clinical and functional outcomes after 2 years in the early detection and intervention for the prevention of psychosis multisite effectiveness trial', Schizophrenia Bulletin, vol. 41, no. 1, pp. 30-43. https://doi.org/10.1093/schbul/sbu108
McFarlane, William R. ; Levin, Bruce ; Travis, Lori ; Lucas, F. Lee ; Lynch, Sarah ; Verdi, Mary ; Williams, Deanna ; Adelsheim, Steven ; Calkins, Roderick ; Carter, Cameron S. ; Cornblatt, Barbara ; Taylor, Stephan F. ; Auther, Andrea M. ; McFarland, Bentson ; Melton, Ryan ; Migliorati, Margaret ; Niendam, Tara ; Ragland, J. Daniel ; Sale, Tamara Grace ; Salvador, Melina ; Spring, Elizabeth. / Clinical and functional outcomes after 2 years in the early detection and intervention for the prevention of psychosis multisite effectiveness trial. In: Schizophrenia Bulletin. 2015 ; Vol. 41, No. 1. pp. 30-43.
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