Clinical and experimental neurotoxicity of 2‐t‐butylazo‐2‐hydroxy‐5‐methylhexane

Peter S. Spencer, Christan M. Beaubernard, Monica C. Bischoff‐Fenton, Thomas L. Kurt

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Seven workers developed weight loss, sensorimotor neuropathy, visual dysfunction, impaired mentation, and emotional lability shortly after the introduction of a new synthetic catalyst in a plant manufacturing reinfoced bathtubs. The newly introduced catalyst, 2‐t‐butylazo‐2‐hydroxy‐5‐methylhexane, is shown to produce a similar syndrome in rats. Axonal degenration of optic nerves, ascending and descending spinal tracts, and peripheral nerves appears to underlie this syndrome.

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
JournalAnnals of Neurology
Issue number1
StatePublished - Jan 1985
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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