TY - JOUR
T1 - Clinical and experimental neurotoxicity of 2‐t‐butylazo‐2‐hydroxy‐5‐methylhexane
AU - Spencer, Peter S.
AU - Beaubernard, Christan M.
AU - Bischoff‐Fenton, Monica C.
AU - Kurt, Thomas L.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1985/1
Y1 - 1985/1
N2 - Seven workers developed weight loss, sensorimotor neuropathy, visual dysfunction, impaired mentation, and emotional lability shortly after the introduction of a new synthetic catalyst in a plant manufacturing reinfoced bathtubs. The newly introduced catalyst, 2‐t‐butylazo‐2‐hydroxy‐5‐methylhexane, is shown to produce a similar syndrome in rats. Axonal degenration of optic nerves, ascending and descending spinal tracts, and peripheral nerves appears to underlie this syndrome.
AB - Seven workers developed weight loss, sensorimotor neuropathy, visual dysfunction, impaired mentation, and emotional lability shortly after the introduction of a new synthetic catalyst in a plant manufacturing reinfoced bathtubs. The newly introduced catalyst, 2‐t‐butylazo‐2‐hydroxy‐5‐methylhexane, is shown to produce a similar syndrome in rats. Axonal degenration of optic nerves, ascending and descending spinal tracts, and peripheral nerves appears to underlie this syndrome.
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U2 - 10.1002/ana.410170108
DO - 10.1002/ana.410170108
M3 - Article
C2 - 3985582
AN - SCOPUS:0021920855
SN - 0364-5134
VL - 17
SP - 28
EP - 32
JO - Annals of Neurology
JF - Annals of Neurology
IS - 1
ER -