Clinical and experimental neurotoxicity of 2-t-butylazo-2-hydroxy-5-methylhexane

Peter Spencer, C. M. Beaubernard, M. C. Bischoff-Fenton, T. L. Kurt

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Seven workers developed weight loss, sensorimotor neuropathy, visual dysfunction, impaired mentation, and emotional lability shortly after the introduction of a new synthetic catalyst in a plant manufacturing reinforced bathtubs. The newly introduced catalyst, 2-t-butylazo-2-hydroxy-5-methylhexane, is shown to produce a similar syndrome in rats. Axonal degeneration of optic nerves, ascending and descending spinal tracts, and peripheral nerves appears to underlie this syndrome.

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
JournalAnnals of Neurology
Volume17
Issue number1
StatePublished - 1985
Externally publishedYes

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Spinal Nerves
Optic Nerve
Peripheral Nerves
Weight Loss
Manufacturing and Industrial Facilities

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spencer, P., Beaubernard, C. M., Bischoff-Fenton, M. C., & Kurt, T. L. (1985). Clinical and experimental neurotoxicity of 2-t-butylazo-2-hydroxy-5-methylhexane. Annals of Neurology, 17(1), 28-32.

Clinical and experimental neurotoxicity of 2-t-butylazo-2-hydroxy-5-methylhexane. / Spencer, Peter; Beaubernard, C. M.; Bischoff-Fenton, M. C.; Kurt, T. L.

In: Annals of Neurology, Vol. 17, No. 1, 1985, p. 28-32.

Research output: Contribution to journalArticle

Spencer, P, Beaubernard, CM, Bischoff-Fenton, MC & Kurt, TL 1985, 'Clinical and experimental neurotoxicity of 2-t-butylazo-2-hydroxy-5-methylhexane', Annals of Neurology, vol. 17, no. 1, pp. 28-32.
Spencer, Peter ; Beaubernard, C. M. ; Bischoff-Fenton, M. C. ; Kurt, T. L. / Clinical and experimental neurotoxicity of 2-t-butylazo-2-hydroxy-5-methylhexane. In: Annals of Neurology. 1985 ; Vol. 17, No. 1. pp. 28-32.
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