Clinical and ethical implications of mitochondrial gene transfer

Shoukhrat Mitalipov, Don P. Wolf

    Research output: Contribution to journalComment/debatepeer-review

    49 Scopus citations


    Inherited diseases caused by mitochondrial gene (mtDNA) mutations affect at least 1 in 5000-10000 children and are associated with severe clinical symptoms. Novel reproductive techniques designed to replace mutated mtDNA in oocytes or early embryos have been proposed to prevent transmission of disease from parents to their children. Here we review the efficacy and safety of these approaches and their associated ethical and regulatory issues.

    Original languageEnglish (US)
    Pages (from-to)5-7
    Number of pages3
    JournalTrends in Endocrinology and Metabolism
    Issue number1
    StatePublished - Jan 2014


    • Assisted reproductive technologies
    • mtDNA mutations

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology


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