Clearance of glutamate inside the synapse and beyond

Dwight E. Bergles, Jeffrey S. Diamond, Craig Jahr

Research output: Contribution to journalArticle

263 Citations (Scopus)

Abstract

The heated debate over the level of postsynaptic receptor occupancy by transmitter has not been extinguished - indeed, new evidence is fanning the flames. Recent experiments using two-photon microscopy suggest that the concentration of glutamate in the synaptic cleft does not attain levels previously suggested. In contrast, recordings from glial cells and studies of extrasynaptic receptor activation indicate that significant quantities of glutamate escape from the cleft following exocytosis. Determining the amount of glutamate efflux from the synaptic cleft and the distance it diffuses is critical to issues of synaptic specificity and the induction of synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)293-298
Number of pages6
JournalCurrent Opinion in Neurobiology
Volume9
Issue number3
DOIs
StatePublished - Jun 1999

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Synapses
Glutamic Acid
Neuronal Plasticity
Exocytosis
Photons
Neuroglia
Microscopy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Clearance of glutamate inside the synapse and beyond. / Bergles, Dwight E.; Diamond, Jeffrey S.; Jahr, Craig.

In: Current Opinion in Neurobiology, Vol. 9, No. 3, 06.1999, p. 293-298.

Research output: Contribution to journalArticle

Bergles, Dwight E. ; Diamond, Jeffrey S. ; Jahr, Craig. / Clearance of glutamate inside the synapse and beyond. In: Current Opinion in Neurobiology. 1999 ; Vol. 9, No. 3. pp. 293-298.
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