Classification of single-trial MEG during sentence processing for automated schizophrenia screening

Tingting Xu, Massoud Stephane, Keshab K. Parhi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

This paper presents a novel computer-aided system for assisting schizophrenia (SZ) diagnosis. Power Spectral Density Ratios (PSDRs) covering 7 brain regions and 5 frequency sub-bands are extracted as features, from single-trial magnetoencephalography (MEG) recorded while subjects read sentence stimuli silently. A two-stage feature selection algorithm combining F-score and Adaptive Boosting (Adaboost) model is proposed to rank the features. The top ranked features are used to build a boosted non-linear classifier using linear decision stumps as the base classifiers. A majority voting scheme is employed to combine single trial classification results from each test subject to make final classification decisions. Following a leave-one-out cross validation procedure, the proposed system achieves 82.61% classification accuracy (92.31% specificity and 70% sensitivity) on 13 healthy controls and 10 SZ patients. The most discriminating PSDR features are selected from the right temporal, right parietal and right frontal regions and are related to alpha (8-13Hz) and beta (13-30Hz) frequency ranges. This information may help in gaining knowledge about the abnormal neural oscillations associated with sentence-level language disorder in SZ.

Original languageEnglish (US)
Title of host publication2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Pages363-366
Number of pages4
DOIs
StatePublished - 2013
Externally publishedYes
Event2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013 - San Diego, CA, United States
Duration: Nov 6 2013Nov 8 2013

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Other

Other2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Country/TerritoryUnited States
CitySan Diego, CA
Period11/6/1311/8/13

Keywords

  • Adaboost
  • Classification
  • Computer-aided schizophrenia identification
  • Feature selection
  • Magnetoencephalography (MEG)
  • Power spectral density ratio (PSDR)

ASJC Scopus subject areas

  • Artificial Intelligence
  • Mechanical Engineering

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