Classification of single-trial MEG during sentence processing for automated schizophrenia screening

Tingting Xu, Massoud Stephane, Keshab K. Parhi

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    3 Scopus citations

    Abstract

    This paper presents a novel computer-aided system for assisting schizophrenia (SZ) diagnosis. Power Spectral Density Ratios (PSDRs) covering 7 brain regions and 5 frequency sub-bands are extracted as features, from single-trial magnetoencephalography (MEG) recorded while subjects read sentence stimuli silently. A two-stage feature selection algorithm combining F-score and Adaptive Boosting (Adaboost) model is proposed to rank the features. The top ranked features are used to build a boosted non-linear classifier using linear decision stumps as the base classifiers. A majority voting scheme is employed to combine single trial classification results from each test subject to make final classification decisions. Following a leave-one-out cross validation procedure, the proposed system achieves 82.61% classification accuracy (92.31% specificity and 70% sensitivity) on 13 healthy controls and 10 SZ patients. The most discriminating PSDR features are selected from the right temporal, right parietal and right frontal regions and are related to alpha (8-13Hz) and beta (13-30Hz) frequency ranges. This information may help in gaining knowledge about the abnormal neural oscillations associated with sentence-level language disorder in SZ.

    Original languageEnglish (US)
    Title of host publication2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
    Pages363-366
    Number of pages4
    DOIs
    StatePublished - Dec 1 2013
    Event2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013 - San Diego, CA, United States
    Duration: Nov 6 2013Nov 8 2013

    Publication series

    NameInternational IEEE/EMBS Conference on Neural Engineering, NER
    ISSN (Print)1948-3546
    ISSN (Electronic)1948-3554

    Other

    Other2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
    CountryUnited States
    CitySan Diego, CA
    Period11/6/1311/8/13

    Keywords

    • Adaboost
    • Classification
    • Computer-aided schizophrenia identification
    • Feature selection
    • Magnetoencephalography (MEG)
    • Power spectral density ratio (PSDR)

    ASJC Scopus subject areas

    • Artificial Intelligence
    • Mechanical Engineering

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  • Cite this

    Xu, T., Stephane, M., & Parhi, K. K. (2013). Classification of single-trial MEG during sentence processing for automated schizophrenia screening. In 2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013 (pp. 363-366). [6695947] (International IEEE/EMBS Conference on Neural Engineering, NER). https://doi.org/10.1109/NER.2013.6695947