Classification of schizophrenia with spectro-temporo-spatial MEG patterns in working memory

Nuri F. Ince, Giuseppe Pellizzer, Ahmed H. Tewfik, Katie Nelson, Arthur Leuthold, Kate McClannahan, Massoud Stephane

    Research output: Contribution to journalArticle

    20 Scopus citations

    Abstract

    Objective: To investigate whether temporo-spatial patterns of brain oscillations extracted from multichannel magnetoencephalogram (MEG) recordings in a working memory task can be used successfully as a biometric marker to discriminate between healthy control subjects and patients with schizophrenia. Methods: Five letters appearing sequentially on a screen had to be memorized. The letters constituted a word in one condition and a pronounceable non-word in the other. Power changes of 248 channel MEG data were extracted in frequency sub-bands and a two-step filter and search algorithm was used to select informative features that discriminated patients and controls. Results: The discrimination between patients and controls was greater in the word condition than in the non-word condition. Furthermore, in the word condition, the most discriminant patterns were extracted in delta (1-4 Hz), alpha (12-16 Hz) and beta (16-24 Hz) frequency bands. These features were located in the left dorso-frontal, occipital and left fronto-temporal, respectively. Conclusion: The analysis of the oscillatory patterns of MEG recordings in the working memory task provided a high level of correct classification of patients and controls. Significance: We show, using a newly developed algorithm, that the temporo-spatial patterns of brain oscillations can be used as biometric marker that discriminate schizophrenia patients and healthy controls.

    Original languageEnglish (US)
    Pages (from-to)1123-1134
    Number of pages12
    JournalClinical Neurophysiology
    Volume120
    Issue number6
    DOIs
    StatePublished - Jun 1 2009

    Keywords

    • Classification
    • ERD
    • ERS
    • MEG
    • Schizophrenia
    • Working memory

    ASJC Scopus subject areas

    • Sensory Systems
    • Neurology
    • Clinical Neurology
    • Physiology (medical)

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  • Cite this

    Ince, N. F., Pellizzer, G., Tewfik, A. H., Nelson, K., Leuthold, A., McClannahan, K., & Stephane, M. (2009). Classification of schizophrenia with spectro-temporo-spatial MEG patterns in working memory. Clinical Neurophysiology, 120(6), 1123-1134. https://doi.org/10.1016/j.clinph.2009.04.008