Class A scavenger receptors, macrophages, and atherosclerosis

M. F. Linton, Sergio Fazio

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The scope of this review is to discuss the new advances in our understanding of the role of scavenger receptor class A in the initiation and modulation of the atherosclerotic process. Through the approaches of gene manipulation in the mouse model, a substantial body of literature has accumulated that depicts scavenger receptor class A as a central player in atherogenesis. In studies of scavenger receptor class A overexpression in macrophages through bone marrow transplantation using transgenic donor material, recipient mice with hyperlipidemia caused either by apolipoprotein E or LDL receptor deficiency did not show convincing changes in the degree of atherosclerosis development compared with controls. Conversely, the deletion of the scavenger receptor class A gene in the mouse has shown, in a consistent and significant fashion, that this receptor serves a pro-atherogenic function under hyperlipidemic conditions, as both apolipoprotein E and LDL receptor-deficient mice had reduced atherosclerosis in the absence of scavenger receptor class A. In addition, we have recently shown that C57BL/6 mice are protected from diet-induced atherosclerosis when they lack scavenger receptor class A, and that the macrophage is the cell type responsible for the effect of scavenger receptor class A deficiency in reducing lesion formation in C57BL/6 and LDL receptor null mice. Together, these results demonstrate that macrophage scavenger receptor class A contributes significantly to atherosclerotic lesion formation, and suggest that the uptake of oxidized or modified lipoproteins by vessel wall macrophages is a central process in atherogenesis.

Original languageEnglish (US)
Pages (from-to)489-495
Number of pages7
JournalCurrent Opinion in Lipidology
Volume12
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

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Class A Scavenger Receptors
Macrophages
Atherosclerosis
LDL Receptors
Low Density Lipoprotein Receptor-Related Protein-1
Genes
Scavenger Receptors
Nutrition
Hyperlipidemias
Bone Marrow Transplantation
Inbred C57BL Mouse
Lipoproteins
Bone
Modulation
Diet

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Class A scavenger receptors, macrophages, and atherosclerosis. / Linton, M. F.; Fazio, Sergio.

In: Current Opinion in Lipidology, Vol. 12, No. 5, 2001, p. 489-495.

Research output: Contribution to journalArticle

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