Class A scavenger receptors, macrophages, and atherosclerosis

M. F. Linton, S. Fazio

    Research output: Contribution to journalReview article

    91 Scopus citations

    Abstract

    The scope of this review is to discuss the new advances in our understanding of the role of scavenger receptor class A in the initiation and modulation of the atherosclerotic process. Through the approaches of gene manipulation in the mouse model, a substantial body of literature has accumulated that depicts scavenger receptor class A as a central player in atherogenesis. In studies of scavenger receptor class A overexpression in macrophages through bone marrow transplantation using transgenic donor material, recipient mice with hyperlipidemia caused either by apolipoprotein E or LDL receptor deficiency did not show convincing changes in the degree of atherosclerosis development compared with controls. Conversely, the deletion of the scavenger receptor class A gene in the mouse has shown, in a consistent and significant fashion, that this receptor serves a pro-atherogenic function under hyperlipidemic conditions, as both apolipoprotein E and LDL receptor-deficient mice had reduced atherosclerosis in the absence of scavenger receptor class A. In addition, we have recently shown that C57BL/6 mice are protected from diet-induced atherosclerosis when they lack scavenger receptor class A, and that the macrophage is the cell type responsible for the effect of scavenger receptor class A deficiency in reducing lesion formation in C57BL/6 and LDL receptor null mice. Together, these results demonstrate that macrophage scavenger receptor class A contributes significantly to atherosclerotic lesion formation, and suggest that the uptake of oxidized or modified lipoproteins by vessel wall macrophages is a central process in atherogenesis.

    Original languageEnglish (US)
    Pages (from-to)489-495
    Number of pages7
    JournalCurrent opinion in lipidology
    Volume12
    Issue number5
    DOIs
    StatePublished - Oct 30 2001

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    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Molecular Biology
    • Genetics
    • Nutrition and Dietetics
    • Cardiology and Cardiovascular Medicine
    • Cell Biology

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