TY - JOUR
T1 - Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women
T2 - Women's Interagency HIV Study
AU - Merhi, Zaher O.
AU - Seifer, David B.
AU - Weedon, Jeremy
AU - Adeyemi, Oluwatoyin
AU - Holman, Susan
AU - Anastos, Kathryn
AU - Golub, Elizabeth T.
AU - Young, Mary
AU - Karim, Roksana
AU - Greenblatt, Ruth
AU - Minkoff, Howard
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/7
Y1 - 2012/7
N2 - Objective: To study the correlation between circulating 25-hydroxyvitamin D (25OH-D) levels and serum antimüllerian hormone (AMH) in women enrolled in the Women's Interagency HIV Study. Design: Cross-sectional study. Setting: None. Patient(s): All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age <35 years (n = 128), group 2 with age 35-39 years (n = 119), and group 3 with age ≥40 years (n = 141). Intervention(s): Serum for 25OH-D, AMH, fasting glucose and insulin, and creatinine levels. Main Outcome Measure(s): Correlation between 25OH-D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation. Result(s): After adjusting for all covariates, the regression slope in all participants for total 25OH-D predicting log 10AMH for 25-year-olds (youngest participant) was -0.001 (SE = 0.008); and for 45-year-olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005). Fasting insulin level was negatively correlated with serum AMH. The regression slope for the correlation between 25OH-D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005). There was no association between HIV and AMH. Conclusion(s): A novel relationship is reported between circulating 25OH-D and AMH in women aged ≥40 years, suggesting that 25OH-D deficiency might be associated with lower ovarian reserve in late-reproductive-aged women.
AB - Objective: To study the correlation between circulating 25-hydroxyvitamin D (25OH-D) levels and serum antimüllerian hormone (AMH) in women enrolled in the Women's Interagency HIV Study. Design: Cross-sectional study. Setting: None. Patient(s): All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age <35 years (n = 128), group 2 with age 35-39 years (n = 119), and group 3 with age ≥40 years (n = 141). Intervention(s): Serum for 25OH-D, AMH, fasting glucose and insulin, and creatinine levels. Main Outcome Measure(s): Correlation between 25OH-D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation. Result(s): After adjusting for all covariates, the regression slope in all participants for total 25OH-D predicting log 10AMH for 25-year-olds (youngest participant) was -0.001 (SE = 0.008); and for 45-year-olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005). Fasting insulin level was negatively correlated with serum AMH. The regression slope for the correlation between 25OH-D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005). There was no association between HIV and AMH. Conclusion(s): A novel relationship is reported between circulating 25OH-D and AMH in women aged ≥40 years, suggesting that 25OH-D deficiency might be associated with lower ovarian reserve in late-reproductive-aged women.
KW - HIV
KW - Vitamin D
KW - antimüllerian hormone
KW - insulin resistance
KW - müllerian-inhibiting substance
KW - obesity
KW - ovarian reserve
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U2 - 10.1016/j.fertnstert.2012.03.029
DO - 10.1016/j.fertnstert.2012.03.029
M3 - Article
C2 - 22494925
AN - SCOPUS:84862978184
VL - 98
SP - 228
EP - 234
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 1
ER -