Circulating-tumor DNA as an early detection and diagnostic tool

Timothy M. Butler, Paul Spellman, Joe Gray

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

The development of new circulating-tumor DNA (ctDNA) analysis techniques has led to an explosion of studies demonstrating exciting clinical applications. Non-invasive genotyping can characterize mutations of interest without the need for an invasive biopsy. Serial ctDNA monitoring can assess response to treatment, and potentially identify mechanisms of resistance. Perhaps most excitingly, sensitive ctDNA analysis methods allow for detection of minimally residual disease, predicting recurrence months before clinical presentation. In this review, we highlight several recent, key studies in the ctDNA field and discuss future advances which would further improve patient care.

Original languageEnglish (US)
Pages (from-to)14-21
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume42
DOIs
StatePublished - Feb 1 2017

Fingerprint

DNA
Neoplasms
Explosions
Patient Care
Biopsy
Recurrence
Mutation
Therapeutics

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Circulating-tumor DNA as an early detection and diagnostic tool. / Butler, Timothy M.; Spellman, Paul; Gray, Joe.

In: Current Opinion in Genetics and Development, Vol. 42, 01.02.2017, p. 14-21.

Research output: Contribution to journalReview article

@article{b05cc0c95ecb45cbb6d4810de4217d6f,
title = "Circulating-tumor DNA as an early detection and diagnostic tool",
abstract = "The development of new circulating-tumor DNA (ctDNA) analysis techniques has led to an explosion of studies demonstrating exciting clinical applications. Non-invasive genotyping can characterize mutations of interest without the need for an invasive biopsy. Serial ctDNA monitoring can assess response to treatment, and potentially identify mechanisms of resistance. Perhaps most excitingly, sensitive ctDNA analysis methods allow for detection of minimally residual disease, predicting recurrence months before clinical presentation. In this review, we highlight several recent, key studies in the ctDNA field and discuss future advances which would further improve patient care.",
author = "Butler, {Timothy M.} and Paul Spellman and Joe Gray",
year = "2017",
month = "2",
day = "1",
doi = "10.1016/j.gde.2016.12.003",
language = "English (US)",
volume = "42",
pages = "14--21",
journal = "Current Opinion in Genetics and Development",
issn = "0959-437X",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Circulating-tumor DNA as an early detection and diagnostic tool

AU - Butler, Timothy M.

AU - Spellman, Paul

AU - Gray, Joe

PY - 2017/2/1

Y1 - 2017/2/1

N2 - The development of new circulating-tumor DNA (ctDNA) analysis techniques has led to an explosion of studies demonstrating exciting clinical applications. Non-invasive genotyping can characterize mutations of interest without the need for an invasive biopsy. Serial ctDNA monitoring can assess response to treatment, and potentially identify mechanisms of resistance. Perhaps most excitingly, sensitive ctDNA analysis methods allow for detection of minimally residual disease, predicting recurrence months before clinical presentation. In this review, we highlight several recent, key studies in the ctDNA field and discuss future advances which would further improve patient care.

AB - The development of new circulating-tumor DNA (ctDNA) analysis techniques has led to an explosion of studies demonstrating exciting clinical applications. Non-invasive genotyping can characterize mutations of interest without the need for an invasive biopsy. Serial ctDNA monitoring can assess response to treatment, and potentially identify mechanisms of resistance. Perhaps most excitingly, sensitive ctDNA analysis methods allow for detection of minimally residual disease, predicting recurrence months before clinical presentation. In this review, we highlight several recent, key studies in the ctDNA field and discuss future advances which would further improve patient care.

UR - http://www.scopus.com/inward/record.url?scp=85010210497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010210497&partnerID=8YFLogxK

U2 - 10.1016/j.gde.2016.12.003

DO - 10.1016/j.gde.2016.12.003

M3 - Review article

C2 - 28126649

AN - SCOPUS:85010210497

VL - 42

SP - 14

EP - 21

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

SN - 0959-437X

ER -