Abstract
With prostate cancer (PCa), circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) portend a poor clinical prognosis. Their unknown biology precludes rational therapeutic design. We demonstrate that CTC and DTC cell lines, established from mice bearing human PCa orthotopic implants, exhibit increased cellular invasion in vitro, increased metastasis in mice, and express increased epithelial to mesenchymal transition biomarkers. Further, they are selectively resistant to growth inhibition by mitoxantrone-like agents. These findings demonstrate that CTC formation is accompanied by phenotypic progression without obligate reversion. Their increased metastatic potential, selective therapeutic resistance, and differential expression of potential therapeutic targets provide a rational basis to test further interventions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 179-186 |
| Number of pages | 8 |
| Journal | Cancer Letters |
| Volume | 352 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 1 2014 |
| Externally published | Yes |
Fingerprint
Keywords
- Circulating tumor cells
- Drug resistance
- EMT
- Metastasis
- MMP-2
- Prostate cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Circulating tumor cells exhibit a biologically aggressive cancer phenotype accompanied by selective resistance to chemotherapy. / Pavese, Janet M.; Bergan, Raymond.
In: Cancer Letters, Vol. 352, No. 2, 01.10.2014, p. 179-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Circulating tumor cells exhibit a biologically aggressive cancer phenotype accompanied by selective resistance to chemotherapy
AU - Pavese, Janet M.
AU - Bergan, Raymond
PY - 2014/10/1
Y1 - 2014/10/1
N2 - With prostate cancer (PCa), circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) portend a poor clinical prognosis. Their unknown biology precludes rational therapeutic design. We demonstrate that CTC and DTC cell lines, established from mice bearing human PCa orthotopic implants, exhibit increased cellular invasion in vitro, increased metastasis in mice, and express increased epithelial to mesenchymal transition biomarkers. Further, they are selectively resistant to growth inhibition by mitoxantrone-like agents. These findings demonstrate that CTC formation is accompanied by phenotypic progression without obligate reversion. Their increased metastatic potential, selective therapeutic resistance, and differential expression of potential therapeutic targets provide a rational basis to test further interventions.
AB - With prostate cancer (PCa), circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) portend a poor clinical prognosis. Their unknown biology precludes rational therapeutic design. We demonstrate that CTC and DTC cell lines, established from mice bearing human PCa orthotopic implants, exhibit increased cellular invasion in vitro, increased metastasis in mice, and express increased epithelial to mesenchymal transition biomarkers. Further, they are selectively resistant to growth inhibition by mitoxantrone-like agents. These findings demonstrate that CTC formation is accompanied by phenotypic progression without obligate reversion. Their increased metastatic potential, selective therapeutic resistance, and differential expression of potential therapeutic targets provide a rational basis to test further interventions.
KW - Circulating tumor cells
KW - Drug resistance
KW - EMT
KW - Metastasis
KW - MMP-2
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=84906053458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906053458&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2014.06.012
DO - 10.1016/j.canlet.2014.06.012
M3 - Article
VL - 352
SP - 179
EP - 186
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 2
ER -