Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke

Wayne Clark, Bruce M. Coull, Dennis P. Briley, Elizabeth Mainolfi, Robert Rothlein

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

To examine whether changes in leukocyte adhesion properties occur during stroke, we measured circulating serum intercellular adhesion molecule 1 (cICAM-1) levels and neutrophil adhesion in acute stroke, patients at high risk of stroke, and in matched controls. Levels of cICAM-1 were significantly lower in the stroke group (186.2 ± 15.6 ng ml-1) compared to controls (257.7 ± 24.8) and risks (257.7 ± 16.5). Neutrophil adhesion was significantly higher in the stroke group (23.6 ± 4.3%; n = 14) compared to controls (9.7 ± 2.3%; n = 12) and risks (12.7 ± 2.5%; n = 13). These data suggest that changes in leukocyte adhesion dynamics are occuring in acute stroke.

Original languageEnglish (US)
Pages (from-to)123-125
Number of pages3
JournalJournal of Neuroimmunology
Volume44
Issue number1
DOIs
StatePublished - 1993

Fingerprint

Intercellular Adhesion Molecule-1
Neutrophils
Stroke
Leukocytes
Serum

Keywords

  • Cell adhesion
  • Intercellular adhesion molecules
  • Leukocytes
  • Stroke

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke. / Clark, Wayne; Coull, Bruce M.; Briley, Dennis P.; Mainolfi, Elizabeth; Rothlein, Robert.

In: Journal of Neuroimmunology, Vol. 44, No. 1, 1993, p. 123-125.

Research output: Contribution to journalArticle

Clark, Wayne ; Coull, Bruce M. ; Briley, Dennis P. ; Mainolfi, Elizabeth ; Rothlein, Robert. / Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke. In: Journal of Neuroimmunology. 1993 ; Vol. 44, No. 1. pp. 123-125.
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