Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke

Wayne M. Clark; Bruce M. Coull; Dennis P. Briley; Elizabeth Mainolfi; Robert Rothlein

doi:10.1016/0165-5728(93)90275-4

Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke

Wayne M. Clark, Bruce M. Coull, Dennis P. Briley, Elizabeth Mainolfi, Robert Rothlein

Neurology

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

To examine whether changes in leukocyte adhesion properties occur during stroke, we measured circulating serum intercellular adhesion molecule 1 (cICAM-1) levels and neutrophil adhesion in acute stroke, patients at high risk of stroke, and in matched controls. Levels of cICAM-1 were significantly lower in the stroke group (186.2 ± 15.6 ng ml^-1) compared to controls (257.7 ± 24.8) and risks (257.7 ± 16.5). Neutrophil adhesion was significantly higher in the stroke group (23.6 ± 4.3%; n = 14) compared to controls (9.7 ± 2.3%; n = 12) and risks (12.7 ± 2.5%; n = 13). These data suggest that changes in leukocyte adhesion dynamics are occuring in acute stroke.

Original language	English (US)
Pages (from-to)	123-125
Number of pages	3
Journal	Journal of Neuroimmunology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/0165-5728(93)90275-4
State	Published - Apr 1993

Keywords

Cell adhesion
Intercellular adhesion molecules
Leukocytes
Stroke

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/0165-5728(93)90275-4

Cite this

@article{c44b20daf4694887a6de4a84746b9943,

title = "Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke",

abstract = "To examine whether changes in leukocyte adhesion properties occur during stroke, we measured circulating serum intercellular adhesion molecule 1 (cICAM-1) levels and neutrophil adhesion in acute stroke, patients at high risk of stroke, and in matched controls. Levels of cICAM-1 were significantly lower in the stroke group (186.2 ± 15.6 ng ml-1) compared to controls (257.7 ± 24.8) and risks (257.7 ± 16.5). Neutrophil adhesion was significantly higher in the stroke group (23.6 ± 4.3%; n = 14) compared to controls (9.7 ± 2.3%; n = 12) and risks (12.7 ± 2.5%; n = 13). These data suggest that changes in leukocyte adhesion dynamics are occuring in acute stroke.",

keywords = "Cell adhesion, Intercellular adhesion molecules, Leukocytes, Stroke",

author = "Clark, {Wayne M.} and Coull, {Bruce M.} and Briley, {Dennis P.} and Elizabeth Mainolfi and Robert Rothlein",

note = "Funding Information: Supported in part by a National Stroke Association/ Allied Signal Inc. Award and a NIH:CIDA award (W.M.C.), and NINDS 2PO1 NS17493-08 (B.M.C.). We acknowledge the assistance of Dr. Karl Arfors, Pharmacia Experimental Medicine, La Jolta, CA, in the development of the adhesion assay.",

year = "1993",

month = apr,

doi = "10.1016/0165-5728(93)90275-4",

language = "English (US)",

volume = "44",

pages = "123--125",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke

AU - Clark, Wayne M.

AU - Coull, Bruce M.

AU - Briley, Dennis P.

AU - Mainolfi, Elizabeth

AU - Rothlein, Robert

N1 - Funding Information: Supported in part by a National Stroke Association/ Allied Signal Inc. Award and a NIH:CIDA award (W.M.C.), and NINDS 2PO1 NS17493-08 (B.M.C.). We acknowledge the assistance of Dr. Karl Arfors, Pharmacia Experimental Medicine, La Jolta, CA, in the development of the adhesion assay.

PY - 1993/4

Y1 - 1993/4

N2 - To examine whether changes in leukocyte adhesion properties occur during stroke, we measured circulating serum intercellular adhesion molecule 1 (cICAM-1) levels and neutrophil adhesion in acute stroke, patients at high risk of stroke, and in matched controls. Levels of cICAM-1 were significantly lower in the stroke group (186.2 ± 15.6 ng ml-1) compared to controls (257.7 ± 24.8) and risks (257.7 ± 16.5). Neutrophil adhesion was significantly higher in the stroke group (23.6 ± 4.3%; n = 14) compared to controls (9.7 ± 2.3%; n = 12) and risks (12.7 ± 2.5%; n = 13). These data suggest that changes in leukocyte adhesion dynamics are occuring in acute stroke.

AB - To examine whether changes in leukocyte adhesion properties occur during stroke, we measured circulating serum intercellular adhesion molecule 1 (cICAM-1) levels and neutrophil adhesion in acute stroke, patients at high risk of stroke, and in matched controls. Levels of cICAM-1 were significantly lower in the stroke group (186.2 ± 15.6 ng ml-1) compared to controls (257.7 ± 24.8) and risks (257.7 ± 16.5). Neutrophil adhesion was significantly higher in the stroke group (23.6 ± 4.3%; n = 14) compared to controls (9.7 ± 2.3%; n = 12) and risks (12.7 ± 2.5%; n = 13). These data suggest that changes in leukocyte adhesion dynamics are occuring in acute stroke.

KW - Cell adhesion

KW - Intercellular adhesion molecules

KW - Leukocytes

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=0027196122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027196122&partnerID=8YFLogxK

U2 - 10.1016/0165-5728(93)90275-4

DO - 10.1016/0165-5728(93)90275-4

M3 - Article

C2 - 8098717

AN - SCOPUS:0027196122

SN - 0165-5728

VL - 44

SP - 123

EP - 125

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1

ER -

Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this